Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury
Objectives Spinal cord injury (SCI) is a disabling central nervous system disorder. This study aimed to explore the effects of repetitive trans-spinal magnetic stimulation (rTSMS) of different spinal cord segments on movement function and growth-associated protein-43 (GAP43) and 5-hydroxytryptamine...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-12-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/0300060520970765 |
| _version_ | 1818742476319490048 |
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| author | Hao Liu Deqi Xiong Rizhao Pang Qian Deng Nianyi Sun Jinqi Zheng Jiancheng Liu Wu Xiang Zhesi Chen Jiachun Lu Wenchun Wang Anren Zhang |
| author_facet | Hao Liu Deqi Xiong Rizhao Pang Qian Deng Nianyi Sun Jinqi Zheng Jiancheng Liu Wu Xiang Zhesi Chen Jiachun Lu Wenchun Wang Anren Zhang |
| author_sort | Hao Liu |
| collection | DOAJ |
| description | Objectives Spinal cord injury (SCI) is a disabling central nervous system disorder. This study aimed to explore the effects of repetitive trans-spinal magnetic stimulation (rTSMS) of different spinal cord segments on movement function and growth-associated protein-43 (GAP43) and 5-hydroxytryptamine (5-HT) expression in rats after acute SCI and to preliminarily discuss the optimal rTSMS treatment site to provide a theoretical foundation and experimental evidence for clinical application of rTSMS in SCI. Methods A rat T10 laminectomy SCI model produced by transient application of an aneurysm clip was used in the study. The rats were divided into group A (sham surgery), group B (acute SCI without stimulation), group C (T6 segment stimulation), group D (T10 segment stimulation), and group E (L2 segment stimulation). Results In vivo magnetic stimulation protected motor function, alleviated myelin sheath damage, decreased NgR and Nogo-A expression levels, increased GAP43 and 5-HT expression levels, and inhibited terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells and apoptosis-related protein expression in rats at 8 weeks after the surgery. Conclusions This study suggests that rTSMS can promote GAP43 and 5-HT expression and axonal regeneration in the spinal cord, which is beneficial to motor function recovery after acute SCI. |
| first_indexed | 2024-12-18T02:13:07Z |
| format | Article |
| id | doaj.art-5df1ba01e7504e7d9918a3f0953f3619 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-18T02:13:07Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-5df1ba01e7504e7d9918a3f0953f36192022-12-21T21:24:26ZengSAGE PublishingJournal of International Medical Research1473-23002020-12-014810.1177/0300060520970765Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injuryHao LiuDeqi XiongRizhao PangQian DengNianyi SunJinqi ZhengJiancheng LiuWu XiangZhesi ChenJiachun LuWenchun WangAnren ZhangObjectives Spinal cord injury (SCI) is a disabling central nervous system disorder. This study aimed to explore the effects of repetitive trans-spinal magnetic stimulation (rTSMS) of different spinal cord segments on movement function and growth-associated protein-43 (GAP43) and 5-hydroxytryptamine (5-HT) expression in rats after acute SCI and to preliminarily discuss the optimal rTSMS treatment site to provide a theoretical foundation and experimental evidence for clinical application of rTSMS in SCI. Methods A rat T10 laminectomy SCI model produced by transient application of an aneurysm clip was used in the study. The rats were divided into group A (sham surgery), group B (acute SCI without stimulation), group C (T6 segment stimulation), group D (T10 segment stimulation), and group E (L2 segment stimulation). Results In vivo magnetic stimulation protected motor function, alleviated myelin sheath damage, decreased NgR and Nogo-A expression levels, increased GAP43 and 5-HT expression levels, and inhibited terminal deoxynucleotidyl transferase dUTP nick end labeling-positive cells and apoptosis-related protein expression in rats at 8 weeks after the surgery. Conclusions This study suggests that rTSMS can promote GAP43 and 5-HT expression and axonal regeneration in the spinal cord, which is beneficial to motor function recovery after acute SCI.https://doi.org/10.1177/0300060520970765 |
| spellingShingle | Hao Liu Deqi Xiong Rizhao Pang Qian Deng Nianyi Sun Jinqi Zheng Jiancheng Liu Wu Xiang Zhesi Chen Jiachun Lu Wenchun Wang Anren Zhang Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury Journal of International Medical Research |
| title | Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury |
| title_full | Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury |
| title_fullStr | Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury |
| title_full_unstemmed | Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury |
| title_short | Effects of repetitive magnetic stimulation on motor function and GAP43 and 5-HT expression in rats with spinal cord injury |
| title_sort | effects of repetitive magnetic stimulation on motor function and gap43 and 5 ht expression in rats with spinal cord injury |
| url | https://doi.org/10.1177/0300060520970765 |
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