The role and mechanism of claudins in cancer
Claudins are a tetraspan membrane protein multigene family that plays a structural and functional role in constructing tight junctions. Claudins perform crucial roles in maintaining cell polarity in epithelial and endothelial cell sheets and controlling paracellular permeability. In the last two dec...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1051497/full |
| _version_ | 1797979165263134720 |
|---|---|
| author | De-Wen Wang De-Wen Wang Wei-Han Zhang Wei-Han Zhang Galiullin Danil Galiullin Danil Galiullin Danil Kun Yang Kun Yang Jian-Kun Hu Jian-Kun Hu |
| author_facet | De-Wen Wang De-Wen Wang Wei-Han Zhang Wei-Han Zhang Galiullin Danil Galiullin Danil Galiullin Danil Kun Yang Kun Yang Jian-Kun Hu Jian-Kun Hu |
| author_sort | De-Wen Wang |
| collection | DOAJ |
| description | Claudins are a tetraspan membrane protein multigene family that plays a structural and functional role in constructing tight junctions. Claudins perform crucial roles in maintaining cell polarity in epithelial and endothelial cell sheets and controlling paracellular permeability. In the last two decades, increasing evidence indicates that claudin proteins play a major role in controlling paracellular permeability and signaling inside cells. Several types of claudins are dysregulated in various cancers. Depending on where the tumor originated, claudin overexpression or underexpression has been shown to regulate cell proliferation, cell growth, metabolism, metastasis and cell stemness. Epithelial-to-mesenchymal transition is one of the most important functions of claudin proteins in disease progression. However, the exact molecular mechanisms and signaling pathways that explain why claudin proteins are so important to tumorigenesis and progression have not been determined. In addition, claudins are currently being investigated as possible diagnostic and treatment targets. Here, we discuss how claudin-related signaling pathways affect tumorigenesis, tumor progression, and treatment sensitivity. |
| first_indexed | 2024-04-11T05:34:40Z |
| format | Article |
| id | doaj.art-5df2da937e664178a75108795cd5f3b5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T05:34:40Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5df2da937e664178a75108795cd5f3b52022-12-22T14:03:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-12-011210.3389/fonc.2022.10514971051497The role and mechanism of claudins in cancerDe-Wen Wang0De-Wen Wang1Wei-Han Zhang2Wei-Han Zhang3Galiullin Danil4Galiullin Danil5Galiullin Danil6Kun Yang7Kun Yang8Jian-Kun Hu9Jian-Kun Hu10Gastric Cancer Center and Laboratory of Gastric Cancer, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaGastric Cancer Center and Laboratory of Gastric Cancer, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaGastric Cancer Center and Laboratory of Gastric Cancer, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaCentral Research Laboratory, Bashkir State Medical University, Ufa, RussiaGastric Cancer Center and Laboratory of Gastric Cancer, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaGastric Cancer Center and Laboratory of Gastric Cancer, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaClaudins are a tetraspan membrane protein multigene family that plays a structural and functional role in constructing tight junctions. Claudins perform crucial roles in maintaining cell polarity in epithelial and endothelial cell sheets and controlling paracellular permeability. In the last two decades, increasing evidence indicates that claudin proteins play a major role in controlling paracellular permeability and signaling inside cells. Several types of claudins are dysregulated in various cancers. Depending on where the tumor originated, claudin overexpression or underexpression has been shown to regulate cell proliferation, cell growth, metabolism, metastasis and cell stemness. Epithelial-to-mesenchymal transition is one of the most important functions of claudin proteins in disease progression. However, the exact molecular mechanisms and signaling pathways that explain why claudin proteins are so important to tumorigenesis and progression have not been determined. In addition, claudins are currently being investigated as possible diagnostic and treatment targets. Here, we discuss how claudin-related signaling pathways affect tumorigenesis, tumor progression, and treatment sensitivity.https://www.frontiersin.org/articles/10.3389/fonc.2022.1051497/fullclaudinsignaling pathwayscancermolecular targeted therapytumor diagnosis |
| spellingShingle | De-Wen Wang De-Wen Wang Wei-Han Zhang Wei-Han Zhang Galiullin Danil Galiullin Danil Galiullin Danil Kun Yang Kun Yang Jian-Kun Hu Jian-Kun Hu The role and mechanism of claudins in cancer Frontiers in Oncology claudin signaling pathways cancer molecular targeted therapy tumor diagnosis |
| title | The role and mechanism of claudins in cancer |
| title_full | The role and mechanism of claudins in cancer |
| title_fullStr | The role and mechanism of claudins in cancer |
| title_full_unstemmed | The role and mechanism of claudins in cancer |
| title_short | The role and mechanism of claudins in cancer |
| title_sort | role and mechanism of claudins in cancer |
| topic | claudin signaling pathways cancer molecular targeted therapy tumor diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1051497/full |
| work_keys_str_mv | AT dewenwang theroleandmechanismofclaudinsincancer AT dewenwang theroleandmechanismofclaudinsincancer AT weihanzhang theroleandmechanismofclaudinsincancer AT weihanzhang theroleandmechanismofclaudinsincancer AT galiullindanil theroleandmechanismofclaudinsincancer AT galiullindanil theroleandmechanismofclaudinsincancer AT galiullindanil theroleandmechanismofclaudinsincancer AT kunyang theroleandmechanismofclaudinsincancer AT kunyang theroleandmechanismofclaudinsincancer AT jiankunhu theroleandmechanismofclaudinsincancer AT jiankunhu theroleandmechanismofclaudinsincancer AT dewenwang roleandmechanismofclaudinsincancer AT dewenwang roleandmechanismofclaudinsincancer AT weihanzhang roleandmechanismofclaudinsincancer AT weihanzhang roleandmechanismofclaudinsincancer AT galiullindanil roleandmechanismofclaudinsincancer AT galiullindanil roleandmechanismofclaudinsincancer AT galiullindanil roleandmechanismofclaudinsincancer AT kunyang roleandmechanismofclaudinsincancer AT kunyang roleandmechanismofclaudinsincancer AT jiankunhu roleandmechanismofclaudinsincancer AT jiankunhu roleandmechanismofclaudinsincancer |