Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking

Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking

Despite 50+ years of clinical use as anxiolytics, anti-convulsants, and sedative/hypnotic agents, the mechanisms underlying benzodiazepine (BZD) tolerance are poorly understood. BZDs potentiate the actions of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain,...

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Bibliographic Details
Main Authors: Joshua M. Lorenz-Guertin, Matthew J. Bambino, Sabyasachi Das, Susan T. Weintraub, Tija C. Jacob
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
GABAAR
benzodiazepine
trafficking
gephyrin
mass spectrometry
diazepam
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00163/full

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