Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India
Exacerbation due to antimicrobial-drug-resistant bacteria among chronic obstructive pulmonary disease (AECOPD) patients contributes to mortality and morbidity. We examined the prevalence of the bacterial organisms and trends in drug resistance in AECOPD. In this retrospective study, between January...
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MDPI AG
2022-11-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/11/11/1577 |
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| author | Mohammed Kaleem Ullah Sowmya Malamardi Jayaraj Biligere Siddaiah Tejashree A Akila Prashant Prashant Vishwanath Lee W. Riley Purnima Madhivanan Padukudru Anand Mahesh |
| author_facet | Mohammed Kaleem Ullah Sowmya Malamardi Jayaraj Biligere Siddaiah Tejashree A Akila Prashant Prashant Vishwanath Lee W. Riley Purnima Madhivanan Padukudru Anand Mahesh |
| author_sort | Mohammed Kaleem Ullah |
| collection | DOAJ |
| description | Exacerbation due to antimicrobial-drug-resistant bacteria among chronic obstructive pulmonary disease (AECOPD) patients contributes to mortality and morbidity. We examined the prevalence of the bacterial organisms and trends in drug resistance in AECOPD. In this retrospective study, between January 2016 to December 2020, among 3027 AECOPD patients, 432 (14.3%) had bacteria isolated. The regression and generalized estimating equations (GEE) were used for trends in the resistance patterns over five years, adjusting for age, gender, and comorbidities. <i>Klebsiella pneumoniae</i> (32.4%), <i>Pseudomonas aeruginosa</i> (17.8%), <i>Acinetobacter baumannii</i> (14.4%), <i>Escherichia coli</i> (10.4%), and <i>Staphylococcus aureus</i> (2.5%) were common. We observed high levels of drug resistance in AECOPD patients admitted to ICU (87.8%) and non-ICU (86.5%). A Cox proportional hazard analysis, observed infection with <i>Acinetobacter baumannii</i> and female sex as independent predictors of mortality. <i>Acinetobacter baumannii</i> had 2.64 (95% confidence interval (CI): 1.08–6.43) higher odds of death, compared to <i>Klebsiella pneumoniae</i>. Females had 2.89 (95% CI: 1.47–5.70) higher odds of death, compared to males. A high proportion of bacterial AECOPD was due to drug-resistant bacteria. An increasing trend in drug resistance was observed among females. |
| first_indexed | 2024-03-09T19:19:01Z |
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| language | English |
| last_indexed | 2024-03-09T19:19:01Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-5df52cce6836453583fbf12fd5abb6c02023-11-24T03:28:39ZengMDPI AGAntibiotics2079-63822022-11-011111157710.3390/antibiotics11111577Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South IndiaMohammed Kaleem Ullah0Sowmya Malamardi1Jayaraj Biligere Siddaiah2Tejashree A3Akila Prashant4Prashant Vishwanath5Lee W. Riley6Purnima Madhivanan7Padukudru Anand Mahesh8Centre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysore 570015, Karnataka, IndiaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, IndiaDepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, IndiaDepartment of Microbiology, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, IndiaCentre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysore 570015, Karnataka, IndiaCentre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education & Research, Mysore 570015, Karnataka, IndiaDivision of Infectious Disease and Vaccinology, School of Public Health, University of California, Berkeley, CA 94720, USADepartment of Health Promotion Sciences, Mel & Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85724, USADepartment of Respiratory Medicine, JSS Medical College, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, IndiaExacerbation due to antimicrobial-drug-resistant bacteria among chronic obstructive pulmonary disease (AECOPD) patients contributes to mortality and morbidity. We examined the prevalence of the bacterial organisms and trends in drug resistance in AECOPD. In this retrospective study, between January 2016 to December 2020, among 3027 AECOPD patients, 432 (14.3%) had bacteria isolated. The regression and generalized estimating equations (GEE) were used for trends in the resistance patterns over five years, adjusting for age, gender, and comorbidities. <i>Klebsiella pneumoniae</i> (32.4%), <i>Pseudomonas aeruginosa</i> (17.8%), <i>Acinetobacter baumannii</i> (14.4%), <i>Escherichia coli</i> (10.4%), and <i>Staphylococcus aureus</i> (2.5%) were common. We observed high levels of drug resistance in AECOPD patients admitted to ICU (87.8%) and non-ICU (86.5%). A Cox proportional hazard analysis, observed infection with <i>Acinetobacter baumannii</i> and female sex as independent predictors of mortality. <i>Acinetobacter baumannii</i> had 2.64 (95% confidence interval (CI): 1.08–6.43) higher odds of death, compared to <i>Klebsiella pneumoniae</i>. Females had 2.89 (95% CI: 1.47–5.70) higher odds of death, compared to males. A high proportion of bacterial AECOPD was due to drug-resistant bacteria. An increasing trend in drug resistance was observed among females.https://www.mdpi.com/2079-6382/11/11/1577pulmonary diseasechronic obstructive/complicationschronic obstructive/microbiologybacterial infections/microbiologydrug resistancemultiple |
| spellingShingle | Mohammed Kaleem Ullah Sowmya Malamardi Jayaraj Biligere Siddaiah Tejashree A Akila Prashant Prashant Vishwanath Lee W. Riley Purnima Madhivanan Padukudru Anand Mahesh Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India Antibiotics pulmonary disease chronic obstructive/complications chronic obstructive/microbiology bacterial infections/microbiology drug resistance multiple |
| title | Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India |
| title_full | Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India |
| title_fullStr | Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India |
| title_full_unstemmed | Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India |
| title_short | Trends in the Bacterial Prevalence and Antibiotic Resistance Patterns in the Acute Exacerbation of Chronic Obstructive Pulmonary Disease in Hospitalized Patients in South India |
| title_sort | trends in the bacterial prevalence and antibiotic resistance patterns in the acute exacerbation of chronic obstructive pulmonary disease in hospitalized patients in south india |
| topic | pulmonary disease chronic obstructive/complications chronic obstructive/microbiology bacterial infections/microbiology drug resistance multiple |
| url | https://www.mdpi.com/2079-6382/11/11/1577 |
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