Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”
Background: Mastitis is an inflammatory response in the mammary gland that results in huge economic losses in the breeding industry. The aetiology of mastitis is complex, and the pathogenesis has not been fully elucidated. It is commonly believed that mastitis is induced by pathogen infection of the...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123223000607 |
| _version_ | 1797372926900568064 |
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| author | Xiaoyu Hu Zhaoqi He Caijun Zhao Yuhong He Min Qiu Kaihe Xiang Naisheng Zhang Yunhe Fu |
| author_facet | Xiaoyu Hu Zhaoqi He Caijun Zhao Yuhong He Min Qiu Kaihe Xiang Naisheng Zhang Yunhe Fu |
| author_sort | Xiaoyu Hu |
| collection | DOAJ |
| description | Background: Mastitis is an inflammatory response in the mammary gland that results in huge economic losses in the breeding industry. The aetiology of mastitis is complex, and the pathogenesis has not been fully elucidated. It is commonly believed that mastitis is induced by pathogen infection of the mammary gland and induces a local inflammatory response. However, in the clinic, mastitis is often comorbid or secondary to gastric disease, and local control effects targeting the mammary gland are limited. In addition, recent studies have found that the gut/rumen microbiota contributes to the development of mastitis and proposed the gut/rumen–mammary gland axis. Combined with studies indicating that gut/rumen microbiota disturbance can damage the gut mucosa barrier, gut/rumen bacteria and their metabolites can migrate to distal extraintestinal organs. It is believed that the occurrence of mastitis is related not only to the infection of the mammary gland by external pathogenic microorganisms but also to a gastroenterogennic pathogenic pathway. Aim of review: We propose the pathological concept of “gastroenterogennic mastitis” and believe that the gut/rumen–mammary gland axis–mediated pathway is the pathological mechanism of “gastroenterogennic mastitis”. Key scientific concepts of review: To clarify the concept of “gastroenterogennic mastitis” by summarizing reports on the effect of the gut/rumen microbiota on mastitis and the gut/rumen–mammary gland axis–mediated pathway to provide a research basis and direction for further understanding and solving the pathogenesis and difficulties encountered in the prevention of mastitis. |
| first_indexed | 2024-03-08T18:42:52Z |
| format | Article |
| id | doaj.art-5df5375b4b9b4ca2bddaf54b5ab93555 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-03-08T18:42:52Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-5df5375b4b9b4ca2bddaf54b5ab935552023-12-29T04:45:05ZengElsevierJournal of Advanced Research2090-12322024-01-0155159171Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis”Xiaoyu Hu0Zhaoqi He1Caijun Zhao2Yuhong He3Min Qiu4Kaihe Xiang5Naisheng Zhang6Yunhe Fu7Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaCorresponding authors.; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaCorresponding authors.; Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, Jilin Province 130062, ChinaBackground: Mastitis is an inflammatory response in the mammary gland that results in huge economic losses in the breeding industry. The aetiology of mastitis is complex, and the pathogenesis has not been fully elucidated. It is commonly believed that mastitis is induced by pathogen infection of the mammary gland and induces a local inflammatory response. However, in the clinic, mastitis is often comorbid or secondary to gastric disease, and local control effects targeting the mammary gland are limited. In addition, recent studies have found that the gut/rumen microbiota contributes to the development of mastitis and proposed the gut/rumen–mammary gland axis. Combined with studies indicating that gut/rumen microbiota disturbance can damage the gut mucosa barrier, gut/rumen bacteria and their metabolites can migrate to distal extraintestinal organs. It is believed that the occurrence of mastitis is related not only to the infection of the mammary gland by external pathogenic microorganisms but also to a gastroenterogennic pathogenic pathway. Aim of review: We propose the pathological concept of “gastroenterogennic mastitis” and believe that the gut/rumen–mammary gland axis–mediated pathway is the pathological mechanism of “gastroenterogennic mastitis”. Key scientific concepts of review: To clarify the concept of “gastroenterogennic mastitis” by summarizing reports on the effect of the gut/rumen microbiota on mastitis and the gut/rumen–mammary gland axis–mediated pathway to provide a research basis and direction for further understanding and solving the pathogenesis and difficulties encountered in the prevention of mastitis.http://www.sciencedirect.com/science/article/pii/S2090123223000607Dairy cowsGastroenterogennic mastitisGut/rumen-mammary gland axisMicrobiota |
| spellingShingle | Xiaoyu Hu Zhaoqi He Caijun Zhao Yuhong He Min Qiu Kaihe Xiang Naisheng Zhang Yunhe Fu Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis” Journal of Advanced Research Dairy cows Gastroenterogennic mastitis Gut/rumen-mammary gland axis Microbiota |
| title | Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis” |
| title_full | Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis” |
| title_fullStr | Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis” |
| title_full_unstemmed | Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis” |
| title_short | Gut/rumen-mammary gland axis in mastitis: Gut/rumen microbiota–mediated “gastroenterogenic mastitis” |
| title_sort | gut rumen mammary gland axis in mastitis gut rumen microbiota mediated gastroenterogenic mastitis |
| topic | Dairy cows Gastroenterogennic mastitis Gut/rumen-mammary gland axis Microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2090123223000607 |
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