Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation
The study evaluated the antitumor activity of tylopilan, aβ- (1→3) (1→6) linked glucan isolated from fruiting bodies of Tylopilus felleus (Bull.: Fr.) P. Karst. (Boletaceae), and Propionibacterium acnes (P.a.) preparation. The antitumor effect of tylopilan and P.a. used alone or in combination was s...
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| Format: | Article |
| Language: | English |
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Polish Botanical Society
2014-01-01
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| Series: | Acta Societatis Botanicorum Poloniae |
| Subjects: | |
| Online Access: | https://pbsociety.org.pl/journals/index.php/asbp/article/view/1114 |
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| author | Jan Grzybek Izabella Zgórniak-Nowosielska Andrzej Kasprowicz Barbara Zawilińska Stanisław Kohlmunzer |
| author_facet | Jan Grzybek Izabella Zgórniak-Nowosielska Andrzej Kasprowicz Barbara Zawilińska Stanisław Kohlmunzer |
| author_sort | Jan Grzybek |
| collection | DOAJ |
| description | The study evaluated the antitumor activity of tylopilan, aβ- (1→3) (1→6) linked glucan isolated from fruiting bodies of Tylopilus felleus (Bull.: Fr.) P. Karst. (Boletaceae), and Propionibacterium acnes (P.a.) preparation. The antitumor effect of tylopilan and P.a. used alone or in combination was studied in NMRI mice inoculated i.p. with 106 180-TG Crocker tumor cells. All experiments were based on a pretreatment with tylopilan and/or P.a. 5 days and/or 2 h before tumor cell inoculation. Mean survival time (MST) of tumor - bearing mice was significantly prolonged in comparison to control mice by a single injection of tylopilan (25 µg/mouse or 50 µg/mouse) or P.a. (1 mg/mouse). MST was 23.6; 22.8 days in the tylopilan injected mice and 17.5 in the control animals. Tylopilan injected in conjunction with P.a. prolonged signifi-cantly MST in comparison to control mice as well as to tylopilan alone treated mice. We have found that P.a. which stimulate immune response enhanced significantly antitumor activity of tylopilan. The cytotoxicity of tylopilan at concentrations of 300, 150, 75 and 37.5 µg/ml towards 180-TG Crocker cells in vitro studies was evaluated. All examined tylopilan concentrations showed cytotoxic activity. |
| first_indexed | 2024-12-14T22:17:37Z |
| format | Article |
| id | doaj.art-5df53d0a266a4f84af508fbe2e82665f |
| institution | Directory Open Access Journal |
| issn | 2083-9480 |
| language | English |
| last_indexed | 2024-12-14T22:17:37Z |
| publishDate | 2014-01-01 |
| publisher | Polish Botanical Society |
| record_format | Article |
| series | Acta Societatis Botanicorum Poloniae |
| spelling | doaj.art-5df53d0a266a4f84af508fbe2e82665f2022-12-21T22:45:34ZengPolish Botanical SocietyActa Societatis Botanicorum Poloniae2083-94802014-01-01633-429329810.5586/asbp.1994.040850Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparationJan Grzybek0Izabella Zgórniak-Nowosielska1Andrzej Kasprowicz2Barbara Zawilińska3Stanisław Kohlmunzer4Jagiellonian UniversityJagiellonian UniversityJagiellonian UniversityJagiellonian UniversityJagiellonian UniversityThe study evaluated the antitumor activity of tylopilan, aβ- (1→3) (1→6) linked glucan isolated from fruiting bodies of Tylopilus felleus (Bull.: Fr.) P. Karst. (Boletaceae), and Propionibacterium acnes (P.a.) preparation. The antitumor effect of tylopilan and P.a. used alone or in combination was studied in NMRI mice inoculated i.p. with 106 180-TG Crocker tumor cells. All experiments were based on a pretreatment with tylopilan and/or P.a. 5 days and/or 2 h before tumor cell inoculation. Mean survival time (MST) of tumor - bearing mice was significantly prolonged in comparison to control mice by a single injection of tylopilan (25 µg/mouse or 50 µg/mouse) or P.a. (1 mg/mouse). MST was 23.6; 22.8 days in the tylopilan injected mice and 17.5 in the control animals. Tylopilan injected in conjunction with P.a. prolonged signifi-cantly MST in comparison to control mice as well as to tylopilan alone treated mice. We have found that P.a. which stimulate immune response enhanced significantly antitumor activity of tylopilan. The cytotoxicity of tylopilan at concentrations of 300, 150, 75 and 37.5 µg/ml towards 180-TG Crocker cells in vitro studies was evaluated. All examined tylopilan concentrations showed cytotoxic activity.https://pbsociety.org.pl/journals/index.php/asbp/article/view/1114antitumorcytotoxic activitiestylopilanpolysaccharideTylopilus felleus (Bull.: Fr.) P. Karst.(Boletaceae)Propionibacterium acnes preparation |
| spellingShingle | Jan Grzybek Izabella Zgórniak-Nowosielska Andrzej Kasprowicz Barbara Zawilińska Stanisław Kohlmunzer Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation Acta Societatis Botanicorum Poloniae antitumor cytotoxic activities tylopilan polysaccharide Tylopilus felleus (Bull.: Fr.) P. Karst. (Boletaceae) Propionibacterium acnes preparation |
| title | Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation |
| title_full | Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation |
| title_fullStr | Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation |
| title_full_unstemmed | Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation |
| title_short | Antitumor activity of a fungal glucan tylopilan and Propionibacterium acnes preparation |
| title_sort | antitumor activity of a fungal glucan tylopilan and propionibacterium acnes preparation |
| topic | antitumor cytotoxic activities tylopilan polysaccharide Tylopilus felleus (Bull.: Fr.) P. Karst. (Boletaceae) Propionibacterium acnes preparation |
| url | https://pbsociety.org.pl/journals/index.php/asbp/article/view/1114 |
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