Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells

Tocilizumab promotes repair of spinal cord injury by facilitating the restoration of tight junctions between vascular endothelial cells

Abstract Background Our previous study demonstrated that M1 macrophages could impair tight junctions (TJs) between vascular endothelial cells by secreting interleukin-6 (IL-6) after spinal cord injury (SCI). Tocilizumab, as a humanized IL-6 receptor (IL-6R) monoclonal antibody approved for the clini...

Full description

Bibliographic Details
Main Authors: Yang Luo, Fei Yao, Yi Shi, Zhenyu Zhu, Zhaoming Xiao, Xingyu You, Yanchang Liu, Shuisheng Yu, Dasheng Tian, Li Cheng, Meige Zheng, Juehua Jing
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Spinal cord injury
Tocilizumab
Blood-spinal cord barrier
Tight junctions
Axon regeneration
Online Access:https://doi.org/10.1186/s12987-022-00399-9

Similar Items

Similar Items