Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China
Background: To investigate the pathological spectrum of glomerular disease in patients with renal insufficiency (RI) from 2008 to 2017. Methods and results: We calculated the estimated glomerular filtration rate (eGFR) with the Chronic Kidney Disease Epidemiology Collaboration creatinine (CKD-EPI) e...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-01-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/0886022X.2019.1620774 |
| _version_ | 1819100598606233600 |
|---|---|
| author | Liangmei Chen Manyu Luo Changqing Dong Bing Li Weiguang Zhang Ping Nie Juan Liu Xiangmei Chen Ping Luo |
| author_facet | Liangmei Chen Manyu Luo Changqing Dong Bing Li Weiguang Zhang Ping Nie Juan Liu Xiangmei Chen Ping Luo |
| author_sort | Liangmei Chen |
| collection | DOAJ |
| description | Background: To investigate the pathological spectrum of glomerular disease in patients with renal insufficiency (RI) from 2008 to 2017. Methods and results: We calculated the estimated glomerular filtration rate (eGFR) with the Chronic Kidney Disease Epidemiology Collaboration creatinine (CKD-EPI) equation and defined RI as an eGFR <60 ml/min/1.73 m2. A total of 969 RI patients were included in our study. IgA nephropathy (IgAN) was the most common subtype of primary glomerulonephritis (37.2%). The frequencies of IgAN and non-IgA mesangioproliferative glomerulonephritis decreased from 27.3% and 9.5% during 2008–2012 to 20.7% and 2.6% during 2013–2017, respectively. However, the frequency of membranous nephropathy increased from 6.8% to 16.2%. Lupus nephritis was the most common subtype of secondary glomerulonephritis (32.1%). The frequencies of both ANCA-associated systemic vasculitis and diabetic nephropathy increased from 3.8% to 7.6% and from 4.3% to 7.6%, respectively. The number of elderly patients (≥60 years) in our study increased sharply, from 15.6% in 2008 to 35.0% in 2017. Membranous nephropathy, minimal change disease, membranoproliferative glomerulonephritis, lupus nephritis and renal amyloidosis are more frequently observed in the elderly patients than in nonelderly patients (<60 years) (p < .05). Excluding those with acute kidney injury, IgAN was the leading cause of RI (24.9%), followed by membranous nephropathy (13.3%) and lupus nephritis (12.0%). Conclusions: IgAN and lupus nephritis were the most prevalent primary glomerulonephritis and secondary glomerulonephritis in patients with RI, respectively. The frequencies of membranous nephropathy, ANCA-associated systemic vasculitis and diabetic nephropathy increased significantly. The number of elderly patients with RI increased sharply. |
| first_indexed | 2024-12-22T01:05:19Z |
| format | Article |
| id | doaj.art-5df8103826fb4ce5b797bd4893950ec4 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-12-22T01:05:19Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-5df8103826fb4ce5b797bd4893950ec42022-12-21T18:44:06ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492019-01-0141147348010.1080/0886022X.2019.16207741620774Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern ChinaLiangmei Chen0Manyu Luo1Changqing Dong2Bing Li3Weiguang Zhang4Ping Nie5Juan Liu6Xiangmei Chen7Ping Luo8The Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityState Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney DiseaseThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityThe Second Hospital of Jilin UniversityBackground: To investigate the pathological spectrum of glomerular disease in patients with renal insufficiency (RI) from 2008 to 2017. Methods and results: We calculated the estimated glomerular filtration rate (eGFR) with the Chronic Kidney Disease Epidemiology Collaboration creatinine (CKD-EPI) equation and defined RI as an eGFR <60 ml/min/1.73 m2. A total of 969 RI patients were included in our study. IgA nephropathy (IgAN) was the most common subtype of primary glomerulonephritis (37.2%). The frequencies of IgAN and non-IgA mesangioproliferative glomerulonephritis decreased from 27.3% and 9.5% during 2008–2012 to 20.7% and 2.6% during 2013–2017, respectively. However, the frequency of membranous nephropathy increased from 6.8% to 16.2%. Lupus nephritis was the most common subtype of secondary glomerulonephritis (32.1%). The frequencies of both ANCA-associated systemic vasculitis and diabetic nephropathy increased from 3.8% to 7.6% and from 4.3% to 7.6%, respectively. The number of elderly patients (≥60 years) in our study increased sharply, from 15.6% in 2008 to 35.0% in 2017. Membranous nephropathy, minimal change disease, membranoproliferative glomerulonephritis, lupus nephritis and renal amyloidosis are more frequently observed in the elderly patients than in nonelderly patients (<60 years) (p < .05). Excluding those with acute kidney injury, IgAN was the leading cause of RI (24.9%), followed by membranous nephropathy (13.3%) and lupus nephritis (12.0%). Conclusions: IgAN and lupus nephritis were the most prevalent primary glomerulonephritis and secondary glomerulonephritis in patients with RI, respectively. The frequencies of membranous nephropathy, ANCA-associated systemic vasculitis and diabetic nephropathy increased significantly. The number of elderly patients with RI increased sharply.http://dx.doi.org/10.1080/0886022X.2019.1620774glomerular diseasepathologyrenal biopsyrenal insufficiency |
| spellingShingle | Liangmei Chen Manyu Luo Changqing Dong Bing Li Weiguang Zhang Ping Nie Juan Liu Xiangmei Chen Ping Luo Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China Renal Failure glomerular disease pathology renal biopsy renal insufficiency |
| title | Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China |
| title_full | Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China |
| title_fullStr | Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China |
| title_full_unstemmed | Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China |
| title_short | Pathological spectrum of glomerular disease in patients with renal insufficiency: a single-center study in Northeastern China |
| title_sort | pathological spectrum of glomerular disease in patients with renal insufficiency a single center study in northeastern china |
| topic | glomerular disease pathology renal biopsy renal insufficiency |
| url | http://dx.doi.org/10.1080/0886022X.2019.1620774 |
| work_keys_str_mv | AT liangmeichen pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT manyuluo pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT changqingdong pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT bingli pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT weiguangzhang pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT pingnie pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT juanliu pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT xiangmeichen pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina AT pingluo pathologicalspectrumofglomerulardiseaseinpatientswithrenalinsufficiencyasinglecenterstudyinnortheasternchina |