Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus
Jun Xu, Lijun Cao, Yuan Suo, Xiaoqin Xu, Hui Sun, Songao Xu, Xiangyun Zhu, Huijie Yu, Weizhong Cao Department of Emergency Medicine, The First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China Background: The study of the experiment was to display the therapeutic function of insulin-lo...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-10-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/chitosan-microcapsulated-insulin-alleviates-mesenteric-microcirculatio-peer-reviewed-article-IJN |
| _version_ | 1818434381831733248 |
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| author | Xu J Cao L Suo Y Xu X Sun H Xu S Zhu X Yu H Cao W |
| author_facet | Xu J Cao L Suo Y Xu X Sun H Xu S Zhu X Yu H Cao W |
| author_sort | Xu J |
| collection | DOAJ |
| description | Jun Xu, Lijun Cao, Yuan Suo, Xiaoqin Xu, Hui Sun, Songao Xu, Xiangyun Zhu, Huijie Yu, Weizhong Cao Department of Emergency Medicine, The First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China Background: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as compared to free insulin. Methods: Diabetic rats were administrated with 24 U/kg insulin or 120 U/kg insulin/chitosan compounds. The blood and mesenteriums were collected, blood glucose levels, arteriole velocity, arteriole diameter, venular diameter, and hemodiapedesis were measured, and COX-2, VCAM-1 expressions were measured in mesenteriums tissues. Results: Both insulin and insulin/chitosan administration decreased blood glucose and improved the state of mesenteric microcirculation through down-regulating COX-2 and VCAM-1 expressions as compared to DM groups, while insulin/chitosan remarkably augmented this functions. Conclusion: Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expressions in rats with DM. Keywords: insulin, chitosan, COX-2, VCAM-1 |
| first_indexed | 2024-12-14T16:36:06Z |
| format | Article |
| id | doaj.art-5df83a796b824890b02b68e7da6735bd |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-14T16:36:06Z |
| publishDate | 2018-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-5df83a796b824890b02b68e7da6735bd2022-12-21T22:54:27ZengDove Medical PressInternational Journal of Nanomedicine1178-20132018-10-01Volume 136829683741758Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitusXu JCao LSuo YXu XSun HXu SZhu XYu HCao WJun Xu, Lijun Cao, Yuan Suo, Xiaoqin Xu, Hui Sun, Songao Xu, Xiangyun Zhu, Huijie Yu, Weizhong Cao Department of Emergency Medicine, The First Hospital of Jiaxing, Jiaxing 314001, Zhejiang Province, China Background: The study of the experiment was to display the therapeutic function of insulin-loaded chitosan (insulin/chitosan) on mesenteric microcirculation via down-regulating cyclooxygenase-2 (COX-2) and vascular cell adhesion molecule (VCAM-1) expressions in rats with diabetes mellitus (DM) as compared to free insulin. Methods: Diabetic rats were administrated with 24 U/kg insulin or 120 U/kg insulin/chitosan compounds. The blood and mesenteriums were collected, blood glucose levels, arteriole velocity, arteriole diameter, venular diameter, and hemodiapedesis were measured, and COX-2, VCAM-1 expressions were measured in mesenteriums tissues. Results: Both insulin and insulin/chitosan administration decreased blood glucose and improved the state of mesenteric microcirculation through down-regulating COX-2 and VCAM-1 expressions as compared to DM groups, while insulin/chitosan remarkably augmented this functions. Conclusion: Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expressions in rats with DM. Keywords: insulin, chitosan, COX-2, VCAM-1https://www.dovepress.com/chitosan-microcapsulated-insulin-alleviates-mesenteric-microcirculatio-peer-reviewed-article-IJNInsulinChitosan;COX-2VCAM-1 |
| spellingShingle | Xu J Cao L Suo Y Xu X Sun H Xu S Zhu X Yu H Cao W Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus International Journal of Nanomedicine Insulin Chitosan;COX-2 VCAM-1 |
| title | Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus |
| title_full | Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus |
| title_fullStr | Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus |
| title_full_unstemmed | Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus |
| title_short | Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus |
| title_sort | chitosan microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating cox 2 and vcam 1 expression in rats with diabetes mellitus |
| topic | Insulin Chitosan;COX-2 VCAM-1 |
| url | https://www.dovepress.com/chitosan-microcapsulated-insulin-alleviates-mesenteric-microcirculatio-peer-reviewed-article-IJN |
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