Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study
Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in h...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-04-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00087/full |
| _version_ | 1818982110276354048 |
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| author | Michihiko eKoeda Atsushi eWatanabe Atsushi eWatanabe Kumiko eTsuda Miwako eMatsumoto Yumiko eIkeda Woochan eKim Amane eTateno Banyar Than eNaing Banyar Than eNaing Hiroyuki eKaribe Takashi eShimada Hidenori eSuzuki Masato eMatsuura Yoshiro eOkubo |
| author_facet | Michihiko eKoeda Atsushi eWatanabe Atsushi eWatanabe Kumiko eTsuda Miwako eMatsumoto Yumiko eIkeda Woochan eKim Amane eTateno Banyar Than eNaing Banyar Than eNaing Hiroyuki eKaribe Takashi eShimada Hidenori eSuzuki Masato eMatsuura Yoshiro eOkubo |
| author_sort | Michihiko eKoeda |
| collection | DOAJ |
| description | Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: 1) rs7794745 (A/A or A/T), 2) rs2710102 (G/G or A carrier (A/G and A/A)), and 3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals. |
| first_indexed | 2024-12-20T17:42:00Z |
| format | Article |
| id | doaj.art-5df892ee3416431b96f9cc778c249180 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-20T17:42:00Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-5df892ee3416431b96f9cc778c2491802022-12-21T19:31:05ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532015-04-01910.3389/fnbeh.2015.00087122374Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI StudyMichihiko eKoeda0Atsushi eWatanabe1Atsushi eWatanabe2Kumiko eTsuda3Miwako eMatsumoto4Yumiko eIkeda5Woochan eKim6Amane eTateno7Banyar Than eNaing8Banyar Than eNaing9Hiroyuki eKaribe10Takashi eShimada11Hidenori eSuzuki12Masato eMatsuura13Yoshiro eOkubo14Nippon Medical SchoolNippon Medical School HospitalGraduate School of Medicine, Nippon Medical SchoolTokyo Medical and Dental UniversityTokyo Medical and Dental UniversityNippon Medical SchoolNippon Medical SchoolNippon Medical SchoolNippon Medical School HospitalGraduate School of Medicine, Nippon Medical SchoolNippon Dental UniversityGraduate School of Medicine, Nippon Medical SchoolNippon Medical SchoolTokyo Medical and Dental UniversityNippon Medical SchoolRecent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these polymorphisms on right-hemispheric function involved in human voice perception. Further, although recent reports suggest that determination of handedness is influenced by genetic effect, the interaction effect between handedness and CNTNAP2 polymorphisms for brain activity in human voice perception and language processing has not been revealed. We aimed to investigate the interaction effect of handedness and CNTNAP2 polymorphisms in respect to brain function for human voice perception and language processing in healthy individuals. Brain function of 108 healthy volunteers (74 right-handed and 34 non-right-handed) was examined while they were passively listening to reverse sentences (rSEN), identifiable non-vocal sounds (SND), and sentences (SEN). Full factorial design analysis was calculated by using three factors: 1) rs7794745 (A/A or A/T), 2) rs2710102 (G/G or A carrier (A/G and A/A)), and 3) voice-specific response (rSEN or SND). The main effect of rs7794745 (A/A or A/T) was significantly revealed at the right middle frontal gyrus (MFG) and bilateral superior temporal gyrus (STG). This result suggests that rs7794745 genotype affects voice-specific brain function. Furthermore, interaction effect was significantly observed among MFG-STG activations by human voice perception, rs7794745 (A/A or A/T), and handedness. These results suggest that CNTNAP2 polymorphisms could be one of the important factors in the neural development related to vocal communication and language processing in both right-handed and non-right-handed healthy individuals.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00087/fullLanguageSchizophreniaVoiceautismfMRIhandedness |
| spellingShingle | Michihiko eKoeda Atsushi eWatanabe Atsushi eWatanabe Kumiko eTsuda Miwako eMatsumoto Yumiko eIkeda Woochan eKim Amane eTateno Banyar Than eNaing Banyar Than eNaing Hiroyuki eKaribe Takashi eShimada Hidenori eSuzuki Masato eMatsuura Yoshiro eOkubo Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study Frontiers in Behavioral Neuroscience Language Schizophrenia Voice autism fMRI handedness |
| title | Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study |
| title_full | Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study |
| title_fullStr | Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study |
| title_full_unstemmed | Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study |
| title_short | Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study |
| title_sort | interaction effect between handedness and cntnap2 polymorphism rs7794745 genotype on voice specific frontotemporal activity in healthy individuals an fmri study |
| topic | Language Schizophrenia Voice autism fMRI handedness |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00087/full |
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