Nuclear protein in testis carcinoma of the lung
Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene located on chromosome 15 q l4, where the most common form of fusion is BRD4-NUT. NUT carcinoma occurred in different organ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523323000268 |
| _version_ | 1797902956235849728 |
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| author | Jing Chen Meihui Li Hongyang Lu |
| author_facet | Jing Chen Meihui Li Hongyang Lu |
| author_sort | Jing Chen |
| collection | DOAJ |
| description | Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene located on chromosome 15 q l4, where the most common form of fusion is BRD4-NUT. NUT carcinoma occurred in different organs and was most commonly found in the midline organs and the lungs. NUT carcinoma can occur in patients of almost all ages, having a roughly consistent incidence in both sexes. Most of the patients were diagnosed in advanced stages with an extremely poor prognosis due to the lack of effective treatment. After years of research, the mechanism of NUT carcinoma is still not fully clear, and its therapeutic approaches need to be further studied and explored. In order to gain a more comprehensive understanding of NUT carcinoma and explore the effective treatments, this review aimed to summarize the clinical features, pathological characteristics, differential diagnosis, and treatment strategies for this disease. |
| first_indexed | 2024-04-10T09:25:23Z |
| format | Article |
| id | doaj.art-5df93c8575454260a34e4ada381a1a8c |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-04-10T09:25:23Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-5df93c8575454260a34e4ada381a1a8c2023-02-20T04:09:00ZengElsevierTranslational Oncology1936-52332023-04-0130101640Nuclear protein in testis carcinoma of the lungJing Chen0Meihui Li1Hongyang Lu2Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Wenzhou Medical University, Wenzhou, 325035, P.R. ChinaZhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; The First Clinical Medical College, Wenzhou Medical University, Wenzhou, 325035, P.R. ChinaZhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China; Corresponding author at: Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (lung and esophagus), Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM); Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Institute of Basic and Cancer Medicine (IBCM), 310022, P.R. China.Nuclear protein in testis (NUT) carcinoma is a kind of highly aggressive and fatal solid tumor characterized by a rearrangement of the NUT carcinoma family member 1 (NUTM1) gene located on chromosome 15 q l4, where the most common form of fusion is BRD4-NUT. NUT carcinoma occurred in different organs and was most commonly found in the midline organs and the lungs. NUT carcinoma can occur in patients of almost all ages, having a roughly consistent incidence in both sexes. Most of the patients were diagnosed in advanced stages with an extremely poor prognosis due to the lack of effective treatment. After years of research, the mechanism of NUT carcinoma is still not fully clear, and its therapeutic approaches need to be further studied and explored. In order to gain a more comprehensive understanding of NUT carcinoma and explore the effective treatments, this review aimed to summarize the clinical features, pathological characteristics, differential diagnosis, and treatment strategies for this disease.http://www.sciencedirect.com/science/article/pii/S1936523323000268NUT carcinomaBRD4-NUTTreatmentPrognosis |
| spellingShingle | Jing Chen Meihui Li Hongyang Lu Nuclear protein in testis carcinoma of the lung Translational Oncology NUT carcinoma BRD4-NUT Treatment Prognosis |
| title | Nuclear protein in testis carcinoma of the lung |
| title_full | Nuclear protein in testis carcinoma of the lung |
| title_fullStr | Nuclear protein in testis carcinoma of the lung |
| title_full_unstemmed | Nuclear protein in testis carcinoma of the lung |
| title_short | Nuclear protein in testis carcinoma of the lung |
| title_sort | nuclear protein in testis carcinoma of the lung |
| topic | NUT carcinoma BRD4-NUT Treatment Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1936523323000268 |
| work_keys_str_mv | AT jingchen nuclearproteinintestiscarcinomaofthelung AT meihuili nuclearproteinintestiscarcinomaofthelung AT hongyanglu nuclearproteinintestiscarcinomaofthelung |