Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based study
Objective: Global thyroid cancer (TC) incidence is growing worldwide, but great heterogenicity exists among published studies, and thus, population-specific epidemiological studies are needed to adequate health resources and evaluate the impact of overdiagnosis. Methods: We conducted a Public Heal...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-04-01
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| Series: | European Thyroid Journal |
| Subjects: | |
| Online Access: | https://etj.bioscientifica.com/view/journals/etj/aop/etj-22-0183/etj-22-0183.xml |
| _version_ | 1797840407036428288 |
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| author | Santiago Tofé Iñaki Argüelles Ana Forteza Cristina Álvarez Alessandra Repetto Luis Masmiquel Irene Rodríguez Eladio Losada Nuria Sukunza María Cabrer Mildred Sifontes María del Mar del Barrio Antonia Barceló Álvaro Tofé Vicente Pereg |
| author_facet | Santiago Tofé Iñaki Argüelles Ana Forteza Cristina Álvarez Alessandra Repetto Luis Masmiquel Irene Rodríguez Eladio Losada Nuria Sukunza María Cabrer Mildred Sifontes María del Mar del Barrio Antonia Barceló Álvaro Tofé Vicente Pereg |
| author_sort | Santiago Tofé |
| collection | DOAJ |
| description | Objective: Global thyroid cancer (TC) incidence is growing worldwide, but great heterogenicity exists among published studies, and thus, population-specific epidemiological studies are needed to adequate health resources and evaluate the impact of overdiagnosis.
Methods: We conducted a Public Health System database retrospective review of TC incident cases from 2000 to 2020 in the Balearic Islands region and evaluated age-standardized incidence rate (ASIR), age at diagnosis, gender distribution, tumor size and histological subtype, mortality rate (MR), and cause of death. Estimated annual percent changes (EAPCs) were also evaluated and data from the 2000–2009 period were compared to the 2010–2020 period when neck ultrasound (US) was routinely performed by clinicians at Endocrinology Departments.
Results: A total of 1387 incident cases of TC were detected. Overall, ASIR (×105) was 5.01 with a 7.82% increment in EAPC. A significant increase in the 2010–2020 period was seen for ASIR (6.99 vs 2.82, P < 0.001) and age at diagnosis (52.11 vs 47.32, P < 0.001) compared to the 2000–2009 period. A reduction in tumor size (2.00 vs 2.78 cm, P < 0.001) and a 6.31% increase in micropapillary TC (P < 0.05) were also seen. Disease-specific MR remained stable at 0.21 (×105). The mean age at diagnosis for all mortality groups was older than survivors (P < 0.001).
Conclusion: The incidence of TC has grown in the 2000–2020 period in the Balearic Islands, but MR has not changed. Beyond other factors, a significant contribution of overdiagnosis to this increased incidence is likely due to changes in the routine management of thyroid nodular disease and increased availability of neck US. |
| first_indexed | 2024-04-09T16:14:36Z |
| format | Article |
| id | doaj.art-5df9f7721a0e479cb53172e237456ad4 |
| institution | Directory Open Access Journal |
| issn | 2235-0802 |
| language | English |
| last_indexed | 2024-04-09T16:14:36Z |
| publishDate | 2023-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj.art-5df9f7721a0e479cb53172e237456ad42023-04-24T06:31:30ZengBioscientificaEuropean Thyroid Journal2235-08022023-04-0112319https://doi.org/10.1530/ETJ-22-0183Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based studySantiago Tofé0Iñaki Argüelles1Ana Forteza2Cristina Álvarez3Alessandra Repetto4Luis Masmiquel5Irene Rodríguez6Eladio Losada7Nuria Sukunza8María Cabrer9Mildred Sifontes10María del Mar del Barrio11Antonia Barceló12Álvaro Tofé13Vicente Pereg14Department of Endocrinology, University Hospital Son Espases, Palma de Mallorca, SpainDepartment of Endocrinology, University Hospital Son Espases, Palma de Mallorca, SpainDepartment of Pathology, University Hospital Son Espases, Palma de Mallorca, SpainDepartment of Surgery, Section of Endocrine Surgery, University Hospital Son Espases, Palma de Mallorca, SpainDepartment of Nuclear Medicine, University Hospital Son Espases, Palma de Mallorca, SpainDepartment of Endocrinology, University Hospital Son Llatzer, Palma de Mallorca, SpainDepartment of Endocrinology, University Hospital Son Llatzer, Palma de Mallorca, SpainDepartment of Endocrinology, Hospital Can Misses, Ibiza, SpainDepartment of Endocrinology, Hospital de Manacor, Manacor, SpainDepartment of Endocrinology, Hospital Comarcal de Inca, Inca, SpainDepartment of Pathology, Hospital Mateu Orfila, Menorca, SpainDepartment of Pathology, Hospital Mateu Orfila, Menorca, SpainDepartment of Laboratory, University Hospital Son Espases, Palma de Mallorca, SpainDepartment of Maxillofacial Surgery, Hospital Puerta del Mar, Cádiz, SpainDepartment of Endocrinology, University Hospital Son Espases, Palma de Mallorca, SpainObjective: Global thyroid cancer (TC) incidence is growing worldwide, but great heterogenicity exists among published studies, and thus, population-specific epidemiological studies are needed to adequate health resources and evaluate the impact of overdiagnosis. Methods: We conducted a Public Health System database retrospective review of TC incident cases from 2000 to 2020 in the Balearic Islands region and evaluated age-standardized incidence rate (ASIR), age at diagnosis, gender distribution, tumor size and histological subtype, mortality rate (MR), and cause of death. Estimated annual percent changes (EAPCs) were also evaluated and data from the 2000–2009 period were compared to the 2010–2020 period when neck ultrasound (US) was routinely performed by clinicians at Endocrinology Departments. Results: A total of 1387 incident cases of TC were detected. Overall, ASIR (×105) was 5.01 with a 7.82% increment in EAPC. A significant increase in the 2010–2020 period was seen for ASIR (6.99 vs 2.82, P < 0.001) and age at diagnosis (52.11 vs 47.32, P < 0.001) compared to the 2000–2009 period. A reduction in tumor size (2.00 vs 2.78 cm, P < 0.001) and a 6.31% increase in micropapillary TC (P < 0.05) were also seen. Disease-specific MR remained stable at 0.21 (×105). The mean age at diagnosis for all mortality groups was older than survivors (P < 0.001). Conclusion: The incidence of TC has grown in the 2000–2020 period in the Balearic Islands, but MR has not changed. Beyond other factors, a significant contribution of overdiagnosis to this increased incidence is likely due to changes in the routine management of thyroid nodular disease and increased availability of neck US.https://etj.bioscientifica.com/view/journals/etj/aop/etj-22-0183/etj-22-0183.xmlage-standardized incidencethyroid cancermortalityoverdiagnosis |
| spellingShingle | Santiago Tofé Iñaki Argüelles Ana Forteza Cristina Álvarez Alessandra Repetto Luis Masmiquel Irene Rodríguez Eladio Losada Nuria Sukunza María Cabrer Mildred Sifontes María del Mar del Barrio Antonia Barceló Álvaro Tofé Vicente Pereg Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based study European Thyroid Journal age-standardized incidence thyroid cancer mortality overdiagnosis |
| title | Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based study |
| title_full | Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based study |
| title_fullStr | Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based study |
| title_full_unstemmed | Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based study |
| title_short | Age-standardized incidence, mortality rate, and trend changes of thyroid cancer in the Balearic Islands during the 2000–2020 period: a population-based study |
| title_sort | age standardized incidence mortality rate and trend changes of thyroid cancer in the balearic islands during the 2000 2020 period a population based study |
| topic | age-standardized incidence thyroid cancer mortality overdiagnosis |
| url | https://etj.bioscientifica.com/view/journals/etj/aop/etj-22-0183/etj-22-0183.xml |
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