Correlation of serum oestrogen level with duration of post operative analgesia
Sixty female patients ofASAstatus I and II posted for routine surgical procedures like abdominal hysterectomy, exploratory laparotomy, pyelolithotomy, laparoscopic cholecystectomy etc. were studied for correlation of serum oestrogen level and post operative analgesia. The patients were divided into...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2007-01-01
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| Series: | Indian Journal of Anaesthesia |
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| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2007;volume=51;issue=6;spage=519;epage=524;aulast=Kumar |
| _version_ | 1819152453198675968 |
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| author | Pramod Kumar K Jaspreet Jigisha Pujara J S Anand |
| author_facet | Pramod Kumar K Jaspreet Jigisha Pujara J S Anand |
| author_sort | Pramod Kumar |
| collection | DOAJ |
| description | Sixty female patients ofASAstatus I and II posted for routine surgical procedures like abdominal hysterectomy, exploratory laparotomy, pyelolithotomy, laparoscopic cholecystectomy etc. were studied for correlation of serum oestrogen level and post operative analgesia. The patients were divided into 3 groups, each consisting of 20 patients. Group-I consisted of female patients in Ist phase of menstrual cycle, Group-II of female patients in II nd phase of menstrual cycle& Group-III of female patients in IIIrd phase of menstrual cycle.All patients were premedicated with glycopyrrolate 4μg.kg -1 and midazolam 0.02 mg.kg -1 intravenously just before induction. All patients were given general anaesthesia with sodium thiopentone 5 mg.kg -1 and succinylcholine 1.5 mg.kg -1 and maintained with O 2 + N 2 O=30:70, fentanyl 1 μg.kg -1 pancuronium 0.08mg.kg -1 bolus and .02 mg.kg -1 given in intermit-tent doses. Patients were reversed with neostigmine 50 μg.kg -1 and glycopyrrolate 8 μg.kg -1 given intravenously slowly. All patients were monitored for pulse, BP, SpO2, RR, tidal volume and minute volume. After recovery of patient, when patient complained of pain, buprenorphine 4μg.kg -1 was given intravenously. Additional supplements of diclofenac sodium were given if needed after the effect of buprenorphine was over upto 24 h. Before induction of anaesthesia, 5ml of patient′s venous blood was collected to measure serum oestrogen level by ELISA method and analgesia after buprenorphine was assessed by VAS score.
The results analysed showed that there was a clinically significant but statistically non significant reduction in 24hr VAS score in Group I& III patients than Group II patients who had a high oestrogen level. A negative correlation between serum oestrogen and mean duration of analgesia further support this, indicating that low serum oestrogen level decreases pain sensitiv-ity and high serum oestrogen level increases pain sensitivity. |
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| institution | Directory Open Access Journal |
| issn | 0019-5049 |
| language | English |
| last_indexed | 2024-12-22T14:49:32Z |
| publishDate | 2007-01-01 |
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| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-5df9fa4348404ecfae599885af973e222022-12-21T18:22:21ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50492007-01-01516519524Correlation of serum oestrogen level with duration of post operative analgesiaPramod KumarK JaspreetJigisha PujaraJ S AnandSixty female patients ofASAstatus I and II posted for routine surgical procedures like abdominal hysterectomy, exploratory laparotomy, pyelolithotomy, laparoscopic cholecystectomy etc. were studied for correlation of serum oestrogen level and post operative analgesia. The patients were divided into 3 groups, each consisting of 20 patients. Group-I consisted of female patients in Ist phase of menstrual cycle, Group-II of female patients in II nd phase of menstrual cycle& Group-III of female patients in IIIrd phase of menstrual cycle.All patients were premedicated with glycopyrrolate 4μg.kg -1 and midazolam 0.02 mg.kg -1 intravenously just before induction. All patients were given general anaesthesia with sodium thiopentone 5 mg.kg -1 and succinylcholine 1.5 mg.kg -1 and maintained with O 2 + N 2 O=30:70, fentanyl 1 μg.kg -1 pancuronium 0.08mg.kg -1 bolus and .02 mg.kg -1 given in intermit-tent doses. Patients were reversed with neostigmine 50 μg.kg -1 and glycopyrrolate 8 μg.kg -1 given intravenously slowly. All patients were monitored for pulse, BP, SpO2, RR, tidal volume and minute volume. After recovery of patient, when patient complained of pain, buprenorphine 4μg.kg -1 was given intravenously. Additional supplements of diclofenac sodium were given if needed after the effect of buprenorphine was over upto 24 h. Before induction of anaesthesia, 5ml of patient′s venous blood was collected to measure serum oestrogen level by ELISA method and analgesia after buprenorphine was assessed by VAS score. The results analysed showed that there was a clinically significant but statistically non significant reduction in 24hr VAS score in Group I& III patients than Group II patients who had a high oestrogen level. A negative correlation between serum oestrogen and mean duration of analgesia further support this, indicating that low serum oestrogen level decreases pain sensitiv-ity and high serum oestrogen level increases pain sensitivity.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2007;volume=51;issue=6;spage=519;epage=524;aulast=KumarSerum oestrogen; Postoperative pain; Gender; Menstrual cycle |
| spellingShingle | Pramod Kumar K Jaspreet Jigisha Pujara J S Anand Correlation of serum oestrogen level with duration of post operative analgesia Indian Journal of Anaesthesia Serum oestrogen; Postoperative pain; Gender; Menstrual cycle |
| title | Correlation of serum oestrogen level with duration of post operative analgesia |
| title_full | Correlation of serum oestrogen level with duration of post operative analgesia |
| title_fullStr | Correlation of serum oestrogen level with duration of post operative analgesia |
| title_full_unstemmed | Correlation of serum oestrogen level with duration of post operative analgesia |
| title_short | Correlation of serum oestrogen level with duration of post operative analgesia |
| title_sort | correlation of serum oestrogen level with duration of post operative analgesia |
| topic | Serum oestrogen; Postoperative pain; Gender; Menstrual cycle |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2007;volume=51;issue=6;spage=519;epage=524;aulast=Kumar |
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