Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched Analysis
(1) <b>Background</b>: This single-center retrospective study aimed to evaluate whether sodium–glucose cotransporter-2 inhibitors (SGLT2-i) therapy may have a nephroprotective effect to prevent contrast-induced acute kidney injury (CI-AKI) in patients with heart failure (HF) undergoing i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/7/2041 |
| _version_ | 1797212359310180352 |
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| author | Giulia Nardi Enrico Marchi Marco Allinovi Gianmarco Lugli Lucrezia Biagiotti Francesca Maria Di Muro Renato Valenti Iacopo Muraca Benedetta Tomberli Niccolò Ciardetti Brunetto Alterini Francesco Meucci Carlo Di Mario Alessio Mattesini |
| author_facet | Giulia Nardi Enrico Marchi Marco Allinovi Gianmarco Lugli Lucrezia Biagiotti Francesca Maria Di Muro Renato Valenti Iacopo Muraca Benedetta Tomberli Niccolò Ciardetti Brunetto Alterini Francesco Meucci Carlo Di Mario Alessio Mattesini |
| author_sort | Giulia Nardi |
| collection | DOAJ |
| description | (1) <b>Background</b>: This single-center retrospective study aimed to evaluate whether sodium–glucose cotransporter-2 inhibitors (SGLT2-i) therapy may have a nephroprotective effect to prevent contrast-induced acute kidney injury (CI-AKI) in patients with heart failure (HF) undergoing iodinated contrast medium (ICM) invasive procedures. (2) <b>Methods</b>: The population was stratified into SGLT2-i users and SGLT2-i non-users according to the chronic treatment with gliflozins. The primary endpoint was CI-AKI incidence during hospitalization. Secondary endpoints were all-cause mortality and the need for continuous renal replacement therapy (CRRT). (3) <b>Results</b>: In total, 86 patients on SGLT2-i and 179 patients not on SGLT2-i were enrolled. The incidence of CI-AKI in the gliflozin group was lower than in the non-user group (9.3 vs. 27.3%, <i>p</i> < 0.001), and these results were confirmed after propensity matching analysis. Multivariable logistic regression showed that only SGLT2-i treatment was an independent preventive factor for CI-AKI (OR: 0.41, 95% CI: 0.16–0.90, <i>p</i> = 0.045). The need for CRRT was reported only in five patients in the non-SGLT2-i-user group compared to zero patients in the gliflozin group (<i>p</i> = 0.05). (4) <b>Conclusions</b>: SGLT2-i therapy was associated with a lower risk of CI-AKI in patients with HF undergoing ICM invasive procedures. |
| first_indexed | 2024-04-24T10:41:08Z |
| format | Article |
| id | doaj.art-5dfdaf1c298446a59ab1245a74428f6b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-24T10:41:08Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5dfdaf1c298446a59ab1245a74428f6b2024-04-12T13:21:23ZengMDPI AGJournal of Clinical Medicine2077-03832024-04-01137204110.3390/jcm13072041Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched AnalysisGiulia Nardi0Enrico Marchi1Marco Allinovi2Gianmarco Lugli3Lucrezia Biagiotti4Francesca Maria Di Muro5Renato Valenti6Iacopo Muraca7Benedetta Tomberli8Niccolò Ciardetti9Brunetto Alterini10Francesco Meucci11Carlo Di Mario12Alessio Mattesini13Department of Experimental and Clinical Medicine, School of Human Health Sciences, Careggi University Hospital, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, Careggi University Hospital, University of Florence, 50134 Florence, ItalyNephrology, Dialysis and Transplantation Unit, Careggi University Hospital, 50134 Florence, ItalyNephrology, Dialysis and Transplantation Unit, Careggi University Hospital, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, Careggi University Hospital, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, Careggi University Hospital, University of Florence, 50134 Florence, ItalyDivision of Interventional Cardiology, Cardiothoracovascular Department, Careggi University Hospital, 50134 Florence, ItalyDivision of Interventional Cardiology, Cardiothoracovascular Department, Careggi University Hospital, 50134 Florence, ItalyDivision of General Cardiology, Cardiothoracovascular Department, Careggi University Hospital, 50134 Florence, ItalyDivision of Structural Interventional Cardiology, Cardiothoracovascular Department, Careggi University Hospital, 50134 Florence, ItalyDivision of Cardiovascular and Perioperative Medicine, Cardiothoracovascular Department, Careggi University Hospital, 50134 Florence, ItalyDivision of Structural Interventional Cardiology, Cardiothoracovascular Department, Careggi University Hospital, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine, School of Human Health Sciences, Careggi University Hospital, University of Florence, 50134 Florence, ItalyDivision of Structural Interventional Cardiology, Cardiothoracovascular Department, Careggi University Hospital, 50134 Florence, Italy(1) <b>Background</b>: This single-center retrospective study aimed to evaluate whether sodium–glucose cotransporter-2 inhibitors (SGLT2-i) therapy may have a nephroprotective effect to prevent contrast-induced acute kidney injury (CI-AKI) in patients with heart failure (HF) undergoing iodinated contrast medium (ICM) invasive procedures. (2) <b>Methods</b>: The population was stratified into SGLT2-i users and SGLT2-i non-users according to the chronic treatment with gliflozins. The primary endpoint was CI-AKI incidence during hospitalization. Secondary endpoints were all-cause mortality and the need for continuous renal replacement therapy (CRRT). (3) <b>Results</b>: In total, 86 patients on SGLT2-i and 179 patients not on SGLT2-i were enrolled. The incidence of CI-AKI in the gliflozin group was lower than in the non-user group (9.3 vs. 27.3%, <i>p</i> < 0.001), and these results were confirmed after propensity matching analysis. Multivariable logistic regression showed that only SGLT2-i treatment was an independent preventive factor for CI-AKI (OR: 0.41, 95% CI: 0.16–0.90, <i>p</i> = 0.045). The need for CRRT was reported only in five patients in the non-SGLT2-i-user group compared to zero patients in the gliflozin group (<i>p</i> = 0.05). (4) <b>Conclusions</b>: SGLT2-i therapy was associated with a lower risk of CI-AKI in patients with HF undergoing ICM invasive procedures.https://www.mdpi.com/2077-0383/13/7/2041contrast-induced acute kidney injurySGLT2-inhibitorsgliflozinsheart failurenephrotoxicity |
| spellingShingle | Giulia Nardi Enrico Marchi Marco Allinovi Gianmarco Lugli Lucrezia Biagiotti Francesca Maria Di Muro Renato Valenti Iacopo Muraca Benedetta Tomberli Niccolò Ciardetti Brunetto Alterini Francesco Meucci Carlo Di Mario Alessio Mattesini Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched Analysis Journal of Clinical Medicine contrast-induced acute kidney injury SGLT2-inhibitors gliflozins heart failure nephrotoxicity |
| title | Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched Analysis |
| title_full | Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched Analysis |
| title_fullStr | Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched Analysis |
| title_full_unstemmed | Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched Analysis |
| title_short | Contrast-Induced Acute Kidney Injury in Patients with Heart Failure on Sodium–Glucose Cotransporter-2 Inhibitors Undergoing Radiocontrast Agent Invasive Procedures: A Propensity-Matched Analysis |
| title_sort | contrast induced acute kidney injury in patients with heart failure on sodium glucose cotransporter 2 inhibitors undergoing radiocontrast agent invasive procedures a propensity matched analysis |
| topic | contrast-induced acute kidney injury SGLT2-inhibitors gliflozins heart failure nephrotoxicity |
| url | https://www.mdpi.com/2077-0383/13/7/2041 |
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