Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection
Abstract Background Recent studies have shown that several systemic inflammatory markers and the nutrition status, including the neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to‐lymphocyte ratio (MLR), platelet‐to‐lymphocyte ratio (PLR), and prognostic nutritional index (PNI), are useful prognostic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.14485 |
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| author | Tadashi Sakane Katsuhiro Okuda Takuya Matsui Risa Oda Tsutomu Tatematsu Keisuke Yokota Ryoichi Nakanishi |
| author_facet | Tadashi Sakane Katsuhiro Okuda Takuya Matsui Risa Oda Tsutomu Tatematsu Keisuke Yokota Ryoichi Nakanishi |
| author_sort | Tadashi Sakane |
| collection | DOAJ |
| description | Abstract Background Recent studies have shown that several systemic inflammatory markers and the nutrition status, including the neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to‐lymphocyte ratio (MLR), platelet‐to‐lymphocyte ratio (PLR), and prognostic nutritional index (PNI), are useful prognostic factors in several malignant tumors. The present study explored the prognostic value of the NLR, MLR, PLR, and PNI in thymic epithelial tumor (TET) patients who underwent complete resection. Methods A total of 158 TET patients who underwent complete resection were involved in the analysis. Their NLR, MLR, PLR, and PNI values were obtained from a blood examination within one month before the initiation of treatment. A receiver operating characteristic curve analysis was conducted to determine the optimal cutoff values. Results The enrolled patients were stratified by cutoffs of 4.35 for the NLR, 0.22 for the MLR, 130.18 for the PLR, and 44.02 for the PNI. A univariate analysis revealed that high‐grade malignant TET, including type B2 and B3 thymoma, thymic carcinoma, and thymic neuroendocrine tumor; an advanced Masaoka stage; a high NLR; a high MLR; and a low PNI were significant predictors of a poor disease‐free survival (DFS). A multivariate analysis confirmed that an advanced Masaoka stage (HR = 5.5557, p = 0.0007) and a high MLR (HR = 3.3371, p = 0.0264) were independent predictors of a poor DFS. Conclusions Our study demonstrated that the pretreatment MLR was an independent predictor of the DFS in patients with TETs who underwent complete resection. |
| first_indexed | 2024-04-13T19:24:33Z |
| format | Article |
| id | doaj.art-5dfdebfbebde47b99616b802f676fdc3 |
| institution | Directory Open Access Journal |
| issn | 1759-7706 1759-7714 |
| language | English |
| last_indexed | 2024-04-13T19:24:33Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj.art-5dfdebfbebde47b99616b802f676fdc32022-12-22T02:33:25ZengWileyThoracic Cancer1759-77061759-77142022-08-0113152127213310.1111/1759-7714.14485Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resectionTadashi Sakane0Katsuhiro Okuda1Takuya Matsui2Risa Oda3Tsutomu Tatematsu4Keisuke Yokota5Ryoichi Nakanishi6Department of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya JapanDepartment of Oncology, Immunology and Surgery Nagoya City University Graduate School of Medical Sciences Nagoya JapanAbstract Background Recent studies have shown that several systemic inflammatory markers and the nutrition status, including the neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to‐lymphocyte ratio (MLR), platelet‐to‐lymphocyte ratio (PLR), and prognostic nutritional index (PNI), are useful prognostic factors in several malignant tumors. The present study explored the prognostic value of the NLR, MLR, PLR, and PNI in thymic epithelial tumor (TET) patients who underwent complete resection. Methods A total of 158 TET patients who underwent complete resection were involved in the analysis. Their NLR, MLR, PLR, and PNI values were obtained from a blood examination within one month before the initiation of treatment. A receiver operating characteristic curve analysis was conducted to determine the optimal cutoff values. Results The enrolled patients were stratified by cutoffs of 4.35 for the NLR, 0.22 for the MLR, 130.18 for the PLR, and 44.02 for the PNI. A univariate analysis revealed that high‐grade malignant TET, including type B2 and B3 thymoma, thymic carcinoma, and thymic neuroendocrine tumor; an advanced Masaoka stage; a high NLR; a high MLR; and a low PNI were significant predictors of a poor disease‐free survival (DFS). A multivariate analysis confirmed that an advanced Masaoka stage (HR = 5.5557, p = 0.0007) and a high MLR (HR = 3.3371, p = 0.0264) were independent predictors of a poor DFS. Conclusions Our study demonstrated that the pretreatment MLR was an independent predictor of the DFS in patients with TETs who underwent complete resection.https://doi.org/10.1111/1759-7714.14485monocyte‐to‐lymphocyte rationeutrophil‐to‐lymphocyte ratioprognostic nutritional indexthymic epithelial tumor |
| spellingShingle | Tadashi Sakane Katsuhiro Okuda Takuya Matsui Risa Oda Tsutomu Tatematsu Keisuke Yokota Ryoichi Nakanishi Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection Thoracic Cancer monocyte‐to‐lymphocyte ratio neutrophil‐to‐lymphocyte ratio prognostic nutritional index thymic epithelial tumor |
| title | Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection |
| title_full | Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection |
| title_fullStr | Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection |
| title_full_unstemmed | Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection |
| title_short | Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection |
| title_sort | prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection |
| topic | monocyte‐to‐lymphocyte ratio neutrophil‐to‐lymphocyte ratio prognostic nutritional index thymic epithelial tumor |
| url | https://doi.org/10.1111/1759-7714.14485 |
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