Over-expression of miR-183-5p or miR-492 triggers invasion and proliferation and loss of polarity in non-neoplastic breast epithelium

Over-expression of miR-183-5p or miR-492 triggers invasion and proliferation and loss of polarity in non-neoplastic breast epithelium

Abstract microRNAs (miRNAs) serve as novel noninvasive cancer biomarkers. In an HMT-3522 S1 (S1) breast epithelial risk-progression three-dimensional (3D) culture model, non-neoplastic S1 cells form a fully polarized epithelium. When silenced for the gap junction and tumor suppressor Cx43, Cx43-KO-S...

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Bibliographic Details
Main Authors:	Nataly Naser Al Deen, Nadia Atallah Lanman, Shirisha Chittiboyina, Sabreen Fostok, Rihab Nasr, Sophie Lelièvre, Rabih Talhouk
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-12-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-022-25663-8

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