Estimation of Solute-Stationary Phase and Solute-Mobile Phase Interactions in the Presence of Ionic Liquids
The presence of free silanols on alkyl-bonded reversed-phase stationary phases is responsible for broad and asymmetrical peaks when basic drugs are chromatographed with conventional octadecylsilane (C18) columns due to ionic interactions. In the last few years, ionic liquids (ILs) have attracted att...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Separations |
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| Online Access: | https://www.mdpi.com/2297-8739/6/3/40 |