A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes
Background: Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 appeared in December 2019 in Wuhan, China. Objective: To investigate the clinical manifestations including signs and symptoms, laboratory results, and perinatal outcomes in pregnant women with C...
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2020-12-01
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| Series: | International Journal of Reproductive BioMedicine |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/ijrm.v18i12.8022 |
| _version_ | 1818428826450919424 |
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| author | Soheil Hassanipour Saeed Bagheri Faradonbeh Khalil Momeni Zahra Heidarifard Mohammad-Javad Khosousi Leila Khosousi Hosein Ameri Morteza Arab-Zozani |
| author_facet | Soheil Hassanipour Saeed Bagheri Faradonbeh Khalil Momeni Zahra Heidarifard Mohammad-Javad Khosousi Leila Khosousi Hosein Ameri Morteza Arab-Zozani |
| author_sort | Soheil Hassanipour |
| collection | DOAJ |
| description | Background: Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 appeared in December 2019 in Wuhan, China.
Objective: To investigate the clinical manifestations including signs and symptoms, laboratory results, and perinatal outcomes in pregnant women with COVID-19.
Materials and Methods: Scholarly databases such as PubMed via LitCovid hub, Embase, Scopus, Web of sciences, and Google scholar were searched on April 7, 2020. Meta-analysis was performed via comprehensive meta-analysis software using the Mantel-Haenszel method. The event rate with 95% CI was calculated for each variable.
Results: Ten studies were selected. The pooled prevalence for fever, post-partum fever, cough, myalgia, fatigue, dyspnea, sore throat, and diarrhea were 66.8%, 37.1%, 35%, 24.6 %, 14.9%, 14.6%, 11.5%, and 7.6%, respectively. Laboratory test results were 49.8% for lymphopenia, 47.7% for leukocytosis, 83.7% for elevated neutrophil ratio, 57% for elevated C-reactive protein, and 71.4% for decreased lymphocyte ratio. The rate of cesarean section for delivery in all cases was 84%. Of the newborns of the corona-positive mothers, only one had a positive test result. Also, there was only one death due to a decreased lymphocyte ratio.
Conclusion: Fever was the most common sign and symptom in pregnant women with COVID-19. Among the laboratory tests, the highest amount was related to elevated neutrophil ratio. It seems that due to the differences between pregnant women and the general population, special measures should be considered to treat these patients. |
| first_indexed | 2024-12-14T15:07:47Z |
| format | Article |
| id | doaj.art-5e00580dcc294feabe54488a86530f17 |
| institution | Directory Open Access Journal |
| issn | 2476-3772 |
| language | English |
| last_indexed | 2024-12-14T15:07:47Z |
| publishDate | 2020-12-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | International Journal of Reproductive BioMedicine |
| spelling | doaj.art-5e00580dcc294feabe54488a86530f172022-12-21T22:56:40ZengShahid Sadoughi University of Medical SciencesInternational Journal of Reproductive BioMedicine2476-37722020-12-01181005101810.18502/ijrm.v18i12.8022ijrm.v18i12.8022A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomesSoheil Hassanipour0Saeed Bagheri Faradonbeh1Khalil Momeni2Zahra Heidarifard3Mohammad-Javad Khosousi4Leila Khosousi5Hosein Ameri6Morteza Arab-Zozani7 Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran. Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.Background: Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 appeared in December 2019 in Wuhan, China. Objective: To investigate the clinical manifestations including signs and symptoms, laboratory results, and perinatal outcomes in pregnant women with COVID-19. Materials and Methods: Scholarly databases such as PubMed via LitCovid hub, Embase, Scopus, Web of sciences, and Google scholar were searched on April 7, 2020. Meta-analysis was performed via comprehensive meta-analysis software using the Mantel-Haenszel method. The event rate with 95% CI was calculated for each variable. Results: Ten studies were selected. The pooled prevalence for fever, post-partum fever, cough, myalgia, fatigue, dyspnea, sore throat, and diarrhea were 66.8%, 37.1%, 35%, 24.6 %, 14.9%, 14.6%, 11.5%, and 7.6%, respectively. Laboratory test results were 49.8% for lymphopenia, 47.7% for leukocytosis, 83.7% for elevated neutrophil ratio, 57% for elevated C-reactive protein, and 71.4% for decreased lymphocyte ratio. The rate of cesarean section for delivery in all cases was 84%. Of the newborns of the corona-positive mothers, only one had a positive test result. Also, there was only one death due to a decreased lymphocyte ratio. Conclusion: Fever was the most common sign and symptom in pregnant women with COVID-19. Among the laboratory tests, the highest amount was related to elevated neutrophil ratio. It seems that due to the differences between pregnant women and the general population, special measures should be considered to treat these patients.https://doi.org/10.18502/ijrm.v18i12.8022covid-19, pregnancy, diagnosis, signs and symptoms, meta-analysis. |
| spellingShingle | Soheil Hassanipour Saeed Bagheri Faradonbeh Khalil Momeni Zahra Heidarifard Mohammad-Javad Khosousi Leila Khosousi Hosein Ameri Morteza Arab-Zozani A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes International Journal of Reproductive BioMedicine covid-19, pregnancy, diagnosis, signs and symptoms, meta-analysis. |
| title | A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes |
| title_full | A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes |
| title_fullStr | A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes |
| title_full_unstemmed | A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes |
| title_short | A systematic review and meta-analysis of pregnancy and COVID-19: Signs and symptoms, laboratory tests, and perinatal outcomes |
| title_sort | systematic review and meta analysis of pregnancy and covid 19 signs and symptoms laboratory tests and perinatal outcomes |
| topic | covid-19, pregnancy, diagnosis, signs and symptoms, meta-analysis. |
| url | https://doi.org/10.18502/ijrm.v18i12.8022 |
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