Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in cats
Background and Aim: Intranasal (IN) sedatives provide a non-invasive route for premedication drug administration. This study compared the cardiorespiratory and sparing effects of IN dexmedetomidine combined with morphine (DM) or tramadol (DT) on alfaxalone requirements for anesthesia induction in ca...
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| Format: | Article |
| Language: | English |
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Veterinary World
2023-06-01
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| Series: | Veterinary World |
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| Online Access: | https://www.veterinaryworld.org/Vol.16/June-2023/3.pdf |
| _version_ | 1797810847505973248 |
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| author | Kewvaree Hommuang Nattika Koatsang Suttiporn Srikullabutr Panpicha Sattasathuchana Naris Thengchaisri |
| author_facet | Kewvaree Hommuang Nattika Koatsang Suttiporn Srikullabutr Panpicha Sattasathuchana Naris Thengchaisri |
| author_sort | Kewvaree Hommuang |
| collection | DOAJ |
| description | Background and Aim: Intranasal (IN) sedatives provide a non-invasive route for premedication drug administration. This study compared the cardiorespiratory and sparing effects of IN dexmedetomidine combined with morphine (DM) or tramadol (DT) on alfaxalone requirements for anesthesia induction in cats.
Materials and Methods: Twenty-four cats were randomly assigned to three groups: Dexmedetomidine combined morphine (IN dexmedetomidine 20 µg/kg plus 0.2 mg/kg morphine), DT (IN dexmedetomidine 20 µg/kg plus 1 mg/kg tramadol), or control (no premedication). The intravenous dose of 1% alfaxalone for endotracheal intubation was recorded with sedation scores, cardiorespiratory parameters (heart rate and respiration rate), and side effects.
Results: Both DM and DT were associated with significantly higher sedation scores than baseline, and sedation scores were found to be highest 20 min after premedication. Sedation scores were comparable between DM and DT groups. Side effects, including hypersalivation, vomiting, and pupillary dilation, were observed in the DM and DT groups. The dosage of alfaxalone required in the DM group (1.5 ± 0.3 mg/kg) was comparable to that of the DT group (2.0 ± 0.6 mg/kg, p = 0.0861), and both groups required significantly less alfaxalone than the control group (3.0 ± 0.6 mg/kg; p < 0.01). Heart and respiratory rates were comparable between the DM and DT groups. Duration of anesthesia in the control group (11 ± 4 min) was significantly shorter than in the DM (29 ± 5 min, p = 0.0016) and DT (38 ± 14 min, p < 0.001) groups.
Conclusion: Intranasal administration of DM or DT produces good sedation and offers an alternative, non-invasive route for cats undergoing general anesthesia. |
| first_indexed | 2024-03-13T07:13:53Z |
| format | Article |
| id | doaj.art-5e019f9bdc42400690d80fa7f5cc6881 |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-03-13T07:13:53Z |
| publishDate | 2023-06-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-5e019f9bdc42400690d80fa7f5cc68812023-06-05T11:42:48ZengVeterinary WorldVeterinary World0972-89882231-09162023-06-011661201120810.14202/vetworld.2023.1201-1208Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in catsKewvaree Hommuang0https://orcid.org/0000-0002-2979-2588Nattika Koatsang1https://orcid.org/0009-0003-5858-3931Suttiporn Srikullabutr2https://orcid.org/0000-0002-2535-4900Panpicha Sattasathuchana3https://orcid.org/0000-0002-9373-6169Naris Thengchaisri4https://orcid.org/0000-0003-0815-0743Department of Clinical Sciences and Public Health, Faculty of Veterinary Sciences, Mahidol University, Salaya, Phutthamonthon District, Nakhon Pathom, 73170, Thailand.Surgery Unit, Kasetsart University Veterinary Teaching Hospital, Bangkok, 10900, Thailand.Department of Companion Animal Clinical Science, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, 10900, Thailand.Background and Aim: Intranasal (IN) sedatives provide a non-invasive route for premedication drug administration. This study compared the cardiorespiratory and sparing effects of IN dexmedetomidine combined with morphine (DM) or tramadol (DT) on alfaxalone requirements for anesthesia induction in cats. Materials and Methods: Twenty-four cats were randomly assigned to three groups: Dexmedetomidine combined morphine (IN dexmedetomidine 20 µg/kg plus 0.2 mg/kg morphine), DT (IN dexmedetomidine 20 µg/kg plus 1 mg/kg tramadol), or control (no premedication). The intravenous dose of 1% alfaxalone for endotracheal intubation was recorded with sedation scores, cardiorespiratory parameters (heart rate and respiration rate), and side effects. Results: Both DM and DT were associated with significantly higher sedation scores than baseline, and sedation scores were found to be highest 20 min after premedication. Sedation scores were comparable between DM and DT groups. Side effects, including hypersalivation, vomiting, and pupillary dilation, were observed in the DM and DT groups. The dosage of alfaxalone required in the DM group (1.5 ± 0.3 mg/kg) was comparable to that of the DT group (2.0 ± 0.6 mg/kg, p = 0.0861), and both groups required significantly less alfaxalone than the control group (3.0 ± 0.6 mg/kg; p < 0.01). Heart and respiratory rates were comparable between the DM and DT groups. Duration of anesthesia in the control group (11 ± 4 min) was significantly shorter than in the DM (29 ± 5 min, p = 0.0016) and DT (38 ± 14 min, p < 0.001) groups. Conclusion: Intranasal administration of DM or DT produces good sedation and offers an alternative, non-invasive route for cats undergoing general anesthesia.https://www.veterinaryworld.org/Vol.16/June-2023/3.pdfalfaxalonedexmedetomidineintranasalmorphinetramadol |
| spellingShingle | Kewvaree Hommuang Nattika Koatsang Suttiporn Srikullabutr Panpicha Sattasathuchana Naris Thengchaisri Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in cats Veterinary World alfaxalone dexmedetomidine intranasal morphine tramadol |
| title | Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in cats |
| title_full | Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in cats |
| title_fullStr | Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in cats |
| title_full_unstemmed | Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in cats |
| title_short | Intranasal dexmedetomidine with morphine or tramadol: A comparative study of effects on alfaxalone requirements for anesthesia in cats |
| title_sort | intranasal dexmedetomidine with morphine or tramadol a comparative study of effects on alfaxalone requirements for anesthesia in cats |
| topic | alfaxalone dexmedetomidine intranasal morphine tramadol |
| url | https://www.veterinaryworld.org/Vol.16/June-2023/3.pdf |
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