Impact of muscular symptoms and/or pain on disease characteristics, disability, and quality of life in adult patients with hypophosphatasia: A cross-sectional analysis from the Global HPP Registry

Impact of muscular symptoms and/or pain on disease characteristics, disability, and quality of life in adult patients with hypophosphatasia: A cross-sectional analysis from the Global HPP Registry

IntroductionHypophosphatasia (HPP) manifests in adults as fractures/pseudofractures, pain, muscle weakness, and other functional impairments. Better phenotypic disease characterization is needed to help recognize disability and treat patients with HPP.MethodsBaseline/pretreatment demographic, clinic...

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Main Authors: Kathryn M. Dahir, Priya S. Kishnani, Gabriel Ángel Martos-Moreno, Agnès Linglart, Anna Petryk, Cheryl Rockman-Greenberg, Samantha E. Martel, Keiichi Ozono, Wolfgang Högler, Lothar Seefried
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
6MWT
rare diseases
alkaline phosphatase
SF-36
health-related quality of life
mobility
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1138599/full

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