<i>MAVS</i> Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4<sup>+</sup> T Cell Infection in HIV-1-Infected Individuals

<i>MAVS</i> Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4<sup>+</sup> T Cell Infection in HIV-1-Infected Individuals

The mitochondrial antiviral protein MAVS is a key player in the induction of antiviral responses; however, human immunodeficiency virus 1 (HIV-1) is able to suppress these responses. Two linked single nucleotide polymorphisms (SNPs) in the <i>MAVS</i> gene render MAVS insensitive to HIV-...

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Bibliographic Details
Main Authors: Melissa Stunnenberg, Lisa van Pul, Joris K. Sprokholt, Karel A. van Dort, Sonja I. Gringhuis, Teunis B. H. Geijtenbeek, Neeltje A. Kootstra
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Viruses
Subjects:
human immunodeficiency virus 1
viral sensing
antiviral immunity
<i>MAVS</i> genetic variation
HIV-1 replication
viral load
Online Access:https://www.mdpi.com/1999-4915/12/7/764

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