JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration

JMJD6 Dysfunction Due to Iron Deficiency in Preeclampsia Disrupts Fibronectin Homeostasis Resulting in Diminished Trophoblast Migration

The mechanisms contributing to excessive fibronectin in preeclampsia, a pregnancy-related disorder, remain unknown. Herein, we investigated the role of JMJD6, an O2- and Fe2+-dependent enzyme, in mediating placental fibronectin processing and function. MALDI-TOF identified fibronectin as a novel tar...

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Bibliográfalaš dieđut
Váldodahkkit: Sruthi Alahari, Abby Farrell, Leonardo Ermini, Chanho Park, Julien Sallais, Sarah Roberts, Taylor Gillmore, Michael Litvack, Martin Post, Isabella Caniggia
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Frontiers Media S.A. 2021-05-01
Ráidu:Frontiers in Cell and Developmental Biology
Fáttát:
fibronectin
iron
JMJD6
pMSCs
preeclampsia
trophoblast migration
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fcell.2021.652607/full

Interneahtta

https://www.frontiersin.org/articles/10.3389/fcell.2021.652607/full

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