Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography
Purpose: The purpose of the study was to evaluate the impact of excessive visceral adipose tissue (VAT) on subclinical coronary atherosclerosis and coronary artery calcifications (CAC) in young and middle-age groups using multislice computed tomography. Methods: This study is a single center, cross-...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2015-07-01
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| Series: | Avicenna Journal of Medicine |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.160242 |
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| author | Rami M Abazid M Obadah Kattea Sawsan Sayed Hanaa Saqqah Mohammed Qintar Osama A Smettei |
| author_facet | Rami M Abazid M Obadah Kattea Sawsan Sayed Hanaa Saqqah Mohammed Qintar Osama A Smettei |
| author_sort | Rami M Abazid |
| collection | DOAJ |
| description | Purpose: The purpose of the study was to evaluate the impact of excessive visceral adipose tissue (VAT) on subclinical coronary atherosclerosis and coronary artery calcifications (CAC) in young and middle-age groups using multislice computed tomography. Methods: This study is a single center, cross-sectional study. Eligible patients (n = 159), who under the age of 61 years, with chest pain and mild to moderate probability to have coronary artery disease (CAD) were enrolled. Coronary calcium score and epicardial adipose tissue (EAT) were measured at the level of the left main coronary artery while VAT was measured at the level of the iliac crest. Results: The average age was (48 ± 8 years). The mean VAT was (38 ± 21 cm 2 ) with no significant difference between men and women (38 ± 22 vs. 37 ± 19 P = 0.8) respectively. Student′s t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively. Univariate regression analysis showed that VAT and EAT, are strong predictor for CAC (hazard ratio [HR] 1.034, 95% confidence interval [CI: 1.016-1.052]. P <0.001 and [HR] 1.344, 95% CI: [1.129-1.601] P = 0.001), respectively. Conclusion: Excessive VAT is significantly associated with positive CAC. VAT can strongly predict subclinical CAD in individuals at young and middle-age groups. |
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| id | doaj.art-5e0b53c7ae3a485783660d4fa3feef1e |
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| issn | 2231-0770 2249-4464 |
| language | English |
| last_indexed | 2024-12-14T15:33:31Z |
| publishDate | 2015-07-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Avicenna Journal of Medicine |
| spelling | doaj.art-5e0b53c7ae3a485783660d4fa3feef1e2022-12-21T22:55:48ZengThieme Medical and Scientific Publishers Pvt. Ltd.Avicenna Journal of Medicine2231-07702249-44642015-07-010503838810.4103/2231-0770.160242Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiographyRami M Abazid0M Obadah Kattea1Sawsan Sayed2Hanaa Saqqah3Mohammed Qintar4Osama A Smettei5Department of Cardiology; Department of Cardiac Imaging, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi ArabiaDepartment of Cardiology; Department of Cardiac Imaging, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi ArabiaDepartment of Cardiology, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi ArabiaDepartment of Cardiac CT Technicians, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi ArabiaDepartment of Internal Medicine, Cleveland Clinic Foundation Cleveland, OH, USADepartment of Cardiology; Department of Cardiac Imaging, Prince Sultan Cardiac Center Al-Qassim, Buraydah, Saudi ArabiaPurpose: The purpose of the study was to evaluate the impact of excessive visceral adipose tissue (VAT) on subclinical coronary atherosclerosis and coronary artery calcifications (CAC) in young and middle-age groups using multislice computed tomography. Methods: This study is a single center, cross-sectional study. Eligible patients (n = 159), who under the age of 61 years, with chest pain and mild to moderate probability to have coronary artery disease (CAD) were enrolled. Coronary calcium score and epicardial adipose tissue (EAT) were measured at the level of the left main coronary artery while VAT was measured at the level of the iliac crest. Results: The average age was (48 ± 8 years). The mean VAT was (38 ± 21 cm 2 ) with no significant difference between men and women (38 ± 22 vs. 37 ± 19 P = 0.8) respectively. Student′s t-test analysis showed significantly higher VAT in patients with detectable CAC than patients with no CAC (48 ± 24 vs. 33 ± 18 P = 0.00002), respectively. Univariate regression analysis showed that VAT and EAT, are strong predictor for CAC (hazard ratio [HR] 1.034, 95% confidence interval [CI: 1.016-1.052]. P <0.001 and [HR] 1.344, 95% CI: [1.129-1.601] P = 0.001), respectively. Conclusion: Excessive VAT is significantly associated with positive CAC. VAT can strongly predict subclinical CAD in individuals at young and middle-age groups.http://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.160242computed tomography-angiographycoronary artery calcificationsvisceral adipose tissue |
| spellingShingle | Rami M Abazid M Obadah Kattea Sawsan Sayed Hanaa Saqqah Mohammed Qintar Osama A Smettei Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography Avicenna Journal of Medicine computed tomography-angiography coronary artery calcifications visceral adipose tissue |
| title | Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography |
| title_full | Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography |
| title_fullStr | Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography |
| title_full_unstemmed | Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography |
| title_short | Visceral adipose tissue influences on coronary artery calcification at young and middle-age groups using computed tomography angiography |
| title_sort | visceral adipose tissue influences on coronary artery calcification at young and middle age groups using computed tomography angiography |
| topic | computed tomography-angiography coronary artery calcifications visceral adipose tissue |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/2231-0770.160242 |
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