Total ginsenoside and Acorus tatarinowii volatile oil co-administration reverses learning memory deficits, reduces Aβ42 and AChE levels, and downregulates the PI3K/Akt/mTOR/Beclin-1 autophagic pathway in APP/PS1 double transgenic mice

Total ginsenoside and Acorus tatarinowii volatile oil co-administration reverses learning memory deficits, reduces Aβ42 and AChE levels, and downregulates the PI3K/Akt/mTOR/Beclin-1 autophagic pathway in APP/PS1 double transgenic mice

Ethnopharmacological Relevance: The combined application of ginseng and Shichangpu comes from the nootropic prescription—Dingzhi Xiaowan. One of the main effective components of ginseng is saponins. Studies have reported that its total saponins have significant neuroprotective effects, especially in...

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Bibliographic Details
Main Authors: Minzhen Deng, Xiaoqin Zhong, Baile Ning, Qinxin Zhang, Yongqi Fang, Liping Huang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research - Modern Chinese Medicine
Subjects:
Total ginsenoside
Volatile oil of Acorus tatarinowii
Autophagy
APP/PS1 double transgenic mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2667142522000045

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