The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases
Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen species, and also have a biological role in antioxidant activities and Ca<sup>2+</sup> buffering. Mitochondri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/7/12/274 |
| _version_ | 1797765613284753408 |
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| author | Saima Kausar Feng Wang Hongjuan Cui |
| author_facet | Saima Kausar Feng Wang Hongjuan Cui |
| author_sort | Saima Kausar |
| collection | DOAJ |
| description | Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen species, and also have a biological role in antioxidant activities and Ca<sup>2+</sup> buffering. Mitochondria are thought to play a crucial biological role in most neurodegenerative disorders. Neurons, being high-energy-demanding cells, are closely related to the maintenance, dynamics, and functions of mitochondria. Thus, impairment of mitochondrial activities is associated with neurodegenerative diseases, pointing to the significance of mitochondrial functions in normal cell physiology. In recent years, considerable progress has been made in our knowledge of mitochondrial functions, which has raised interest in defining the involvement of mitochondrial dysfunction in neurodegenerative diseases. Here, we summarize the existing knowledge of the mitochondrial function in reactive oxygen species generation and its involvement in the development of neurodegenerative diseases. |
| first_indexed | 2024-03-12T20:13:37Z |
| format | Article |
| id | doaj.art-5e0f7e901c87404d85ce009e7c432eef |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T20:13:37Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5e0f7e901c87404d85ce009e7c432eef2023-08-02T01:31:37ZengMDPI AGCells2073-44092018-12-0171227410.3390/cells7120274cells7120274The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative DiseasesSaima Kausar0Feng Wang1Hongjuan Cui2State Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400716, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Beibei, Chongqing 400716, ChinaMitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen species, and also have a biological role in antioxidant activities and Ca<sup>2+</sup> buffering. Mitochondria are thought to play a crucial biological role in most neurodegenerative disorders. Neurons, being high-energy-demanding cells, are closely related to the maintenance, dynamics, and functions of mitochondria. Thus, impairment of mitochondrial activities is associated with neurodegenerative diseases, pointing to the significance of mitochondrial functions in normal cell physiology. In recent years, considerable progress has been made in our knowledge of mitochondrial functions, which has raised interest in defining the involvement of mitochondrial dysfunction in neurodegenerative diseases. Here, we summarize the existing knowledge of the mitochondrial function in reactive oxygen species generation and its involvement in the development of neurodegenerative diseases.https://www.mdpi.com/2073-4409/7/12/274electron transport chainmitochondrianeurodegenerative diseasesoxidative damage |
| spellingShingle | Saima Kausar Feng Wang Hongjuan Cui The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases Cells electron transport chain mitochondria neurodegenerative diseases oxidative damage |
| title | The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases |
| title_full | The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases |
| title_fullStr | The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases |
| title_full_unstemmed | The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases |
| title_short | The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases |
| title_sort | role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases |
| topic | electron transport chain mitochondria neurodegenerative diseases oxidative damage |
| url | https://www.mdpi.com/2073-4409/7/12/274 |
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