Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study
BackgroundPreoperative classification of head and neck (HN) tumors remains challenging, especially distinguishing early cancerogenic masses from benign lesions. Synthetic MRI offers a new way for quantitative analysis of tumors. The present study investigated the application of synthetic MRI and sti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1225420/full |
| _version_ | 1827805038635909120 |
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| author | Baohong Wen Zanxia Zhang Jing Zhu Liang Liu Zijun Liu Xiaoyue Ma Kaiyu Wang Lizhi Xie Yong Zhang Jingliang Cheng |
| author_facet | Baohong Wen Zanxia Zhang Jing Zhu Liang Liu Zijun Liu Xiaoyue Ma Kaiyu Wang Lizhi Xie Yong Zhang Jingliang Cheng |
| author_sort | Baohong Wen |
| collection | DOAJ |
| description | BackgroundPreoperative classification of head and neck (HN) tumors remains challenging, especially distinguishing early cancerogenic masses from benign lesions. Synthetic MRI offers a new way for quantitative analysis of tumors. The present study investigated the application of synthetic MRI and stimulus and fast spin echo diffusion-weighted imaging with periodically rotated overlapping parallel lines with enhanced reconstruction (FSE-PROPELLER DWI) to differentiate malignant from benign HN tumors.Materials and methodsForty-eight patients with pathologically confirmed HN tumors were retrospectively recruited between August 2022 and October 2022. The patients were divided into malignant (n = 28) and benign (n = 20) groups. All patients were scanned using synthetic MRI and FSE-PROPELLER DWI. T1, T2, and proton density (PD) values were acquired on the synthetic MRI and ADC values on the FSE-PROPELLER DWI.ResultsBenign tumors (ADC: 2.03 ± 0.31 × 10-3 mm2/s, T1: 1741.13 ± 662.64 ms, T2: 157.43 ± 72.23 ms) showed higher ADC, T1, and T2 values compared to malignant tumors (ADC: 1.46 ± 0.37 × 10-3 mm2/s, T1: 1390.06 ± 241.09 ms, T2: 97.64 ± 14.91 ms) (all P<0.05), while no differences were seen for PD values. ROC analysis showed that T2+ADC (cut-off value, > 0.55; AUC, 0.950) had optimal diagnostic performance vs. T1 (cut-off value, ≤ 1675.84 ms; AUC, 0.698), T2 (cut-off value, ≤ 113.24 ms; AUC, 0.855) and PD (cut off value, > 80.67 pu; AUC, 0.568) alone in differentiating malignant from benign lesions (all P<0.05); yet, the difference in AUC between ADC and T2+ADC or T2 did not reach statistical significance.ConclusionSynthetic MRI and FSE-PROPELLER DWI can quantitatively differentiate malignant from benign HN tumors. T2 value is comparable to ADC value, and T2+ADC values could improve diagnostic efficacy., apparent diffusion coeffificient, head and neck tumors |
| first_indexed | 2024-03-11T21:19:54Z |
| format | Article |
| id | doaj.art-5e126c1c53e6493fa143946326732914 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-11T21:19:54Z |
| publishDate | 2023-09-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-5e126c1c53e6493fa1439463267329142023-09-28T09:31:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.12254201225420Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary studyBaohong Wen0Zanxia Zhang1Jing Zhu2Liang Liu3Zijun Liu4Xiaoyue Ma5Kaiyu Wang6Lizhi Xie7Yong Zhang8Jingliang Cheng9Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaMR Research China, GE Healthcare, Beijing, ChinaMR Research China, GE Healthcare, Beijing, ChinaDepartment of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaBackgroundPreoperative classification of head and neck (HN) tumors remains challenging, especially distinguishing early cancerogenic masses from benign lesions. Synthetic MRI offers a new way for quantitative analysis of tumors. The present study investigated the application of synthetic MRI and stimulus and fast spin echo diffusion-weighted imaging with periodically rotated overlapping parallel lines with enhanced reconstruction (FSE-PROPELLER DWI) to differentiate malignant from benign HN tumors.Materials and methodsForty-eight patients with pathologically confirmed HN tumors were retrospectively recruited between August 2022 and October 2022. The patients were divided into malignant (n = 28) and benign (n = 20) groups. All patients were scanned using synthetic MRI and FSE-PROPELLER DWI. T1, T2, and proton density (PD) values were acquired on the synthetic MRI and ADC values on the FSE-PROPELLER DWI.ResultsBenign tumors (ADC: 2.03 ± 0.31 × 10-3 mm2/s, T1: 1741.13 ± 662.64 ms, T2: 157.43 ± 72.23 ms) showed higher ADC, T1, and T2 values compared to malignant tumors (ADC: 1.46 ± 0.37 × 10-3 mm2/s, T1: 1390.06 ± 241.09 ms, T2: 97.64 ± 14.91 ms) (all P<0.05), while no differences were seen for PD values. ROC analysis showed that T2+ADC (cut-off value, > 0.55; AUC, 0.950) had optimal diagnostic performance vs. T1 (cut-off value, ≤ 1675.84 ms; AUC, 0.698), T2 (cut-off value, ≤ 113.24 ms; AUC, 0.855) and PD (cut off value, > 80.67 pu; AUC, 0.568) alone in differentiating malignant from benign lesions (all P<0.05); yet, the difference in AUC between ADC and T2+ADC or T2 did not reach statistical significance.ConclusionSynthetic MRI and FSE-PROPELLER DWI can quantitatively differentiate malignant from benign HN tumors. T2 value is comparable to ADC value, and T2+ADC values could improve diagnostic efficacy., apparent diffusion coeffificient, head and neck tumorshttps://www.frontiersin.org/articles/10.3389/fonc.2023.1225420/fullsyntheticmagnetic resonance imagingdiffusion-weighted imageapparent diffusion coefficienthead and neck tumors |
| spellingShingle | Baohong Wen Zanxia Zhang Jing Zhu Liang Liu Zijun Liu Xiaoyue Ma Kaiyu Wang Lizhi Xie Yong Zhang Jingliang Cheng Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study Frontiers in Oncology synthetic magnetic resonance imaging diffusion-weighted image apparent diffusion coefficient head and neck tumors |
| title | Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study |
| title_full | Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study |
| title_fullStr | Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study |
| title_full_unstemmed | Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study |
| title_short | Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study |
| title_sort | synthetic mri plus fse propeller dwi for differentiating malignant from benign head and neck tumors a preliminary study |
| topic | synthetic magnetic resonance imaging diffusion-weighted image apparent diffusion coefficient head and neck tumors |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1225420/full |
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