Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast

Transient DNMT3L Expression Reinforces Chromatin Surveillance to Halt Senescence Progression in Mouse Embryonic Fibroblast

Global heterochromatin reduction, which is one of the hallmarks of senescent cells, is associated with reduced transposable element repression and increased risk of chromatin instability. To ensure genomic integrity, the irreparable cells in a population exit permanently from the cell cycle, and thi...

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Bibliographic Details
Main Authors: Yoyo Chih-Yun Yu, Tony ZK Hui, Tzu-Hao Kao, Hung-Fu Liao, Chih-Yi Yang, Chia-Chun Hou, Hsin-Ting Hsieh, Jen-Yun Chang, Yi-Tzang Tsai, Marina Pinskaya, Kai-Chien Yang, Yet-Ran Chen, Antonin Morillon, Mong-Hsun Tsai, Shau-Ping Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
senescence
epigenetics
DNA methyltransferase 3-like (DNMT3L)
polycomb repressive complex 2 (PRC2)
chromatin surveillance
transposable element (TE)
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00103/full

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