Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-Methyltransferases
The <i>O</i>-methylation of specialized metabolites in plants is a unique decoration that provides structural and functional diversity of the metabolites with changes in chemical properties and intracellular localizations. The <i>O</i>-methylation of flavonoids, which is a cl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/11/4/564 |
| _version_ | 1797477021037625344 |
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| author | Yuting Liu Alisdair R. Fernie Takayuki Tohge |
| author_facet | Yuting Liu Alisdair R. Fernie Takayuki Tohge |
| author_sort | Yuting Liu |
| collection | DOAJ |
| description | The <i>O</i>-methylation of specialized metabolites in plants is a unique decoration that provides structural and functional diversity of the metabolites with changes in chemical properties and intracellular localizations. The <i>O</i>-methylation of flavonoids, which is a class of plant specialized metabolites, promotes their antimicrobial activities and liposolubility. Flavonoid <i>O</i>-methyltransferases (FOMTs), which are responsible for the <i>O</i>-methylation process of the flavonoid aglycone, generally accept a broad range of substrates across flavones, flavonols and lignin precursors, with different substrate preferences. Therefore, the characterization of FOMTs with the physiology roles of methoxylated flavonoids is useful for crop improvement and metabolic engineering. In this review, we summarized the chemodiversity and physiology roles of methoxylated flavonoids, which were already reported, and we performed a cross-species comparison to illustrate an overview of diversification and conserved catalytic sites of the flavonoid <i>O</i>-methyltransferases. |
| first_indexed | 2024-03-09T21:12:02Z |
| format | Article |
| id | doaj.art-5e13a3d887484158804752ee4bbaf506 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-09T21:12:02Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-5e13a3d887484158804752ee4bbaf5062023-11-23T21:43:27ZengMDPI AGPlants2223-77472022-02-0111456410.3390/plants11040564Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-MethyltransferasesYuting Liu0Alisdair R. Fernie1Takayuki Tohge2Graduate School of Biological Science, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, JapanMax-Planck-Institut für Molekulare Pflanzenphysiologie, 14476 Potsdam-Golm, GermanyGraduate School of Biological Science, Nara Institute of Science and Technology (NAIST), Ikoma 630-0192, JapanThe <i>O</i>-methylation of specialized metabolites in plants is a unique decoration that provides structural and functional diversity of the metabolites with changes in chemical properties and intracellular localizations. The <i>O</i>-methylation of flavonoids, which is a class of plant specialized metabolites, promotes their antimicrobial activities and liposolubility. Flavonoid <i>O</i>-methyltransferases (FOMTs), which are responsible for the <i>O</i>-methylation process of the flavonoid aglycone, generally accept a broad range of substrates across flavones, flavonols and lignin precursors, with different substrate preferences. Therefore, the characterization of FOMTs with the physiology roles of methoxylated flavonoids is useful for crop improvement and metabolic engineering. In this review, we summarized the chemodiversity and physiology roles of methoxylated flavonoids, which were already reported, and we performed a cross-species comparison to illustrate an overview of diversification and conserved catalytic sites of the flavonoid <i>O</i>-methyltransferases.https://www.mdpi.com/2223-7747/11/4/564methoxylated flavonoids<i>O</i>-methyltransferaseplant specialized metabolism |
| spellingShingle | Yuting Liu Alisdair R. Fernie Takayuki Tohge Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-Methyltransferases Plants methoxylated flavonoids <i>O</i>-methyltransferase plant specialized metabolism |
| title | Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-Methyltransferases |
| title_full | Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-Methyltransferases |
| title_fullStr | Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-Methyltransferases |
| title_full_unstemmed | Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-Methyltransferases |
| title_short | Diversification of Chemical Structures of Methoxylated Flavonoids and Genes Encoding Flavonoid-<i>O</i>-Methyltransferases |
| title_sort | diversification of chemical structures of methoxylated flavonoids and genes encoding flavonoid i o i methyltransferases |
| topic | methoxylated flavonoids <i>O</i>-methyltransferase plant specialized metabolism |
| url | https://www.mdpi.com/2223-7747/11/4/564 |
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