Mid term results after bone marrow laser revascularization for treating refractory angina
<p>Abstract</p> <p>Background</p> <p>To evaluate the midterm results of patients with angina and diffuse coronary artery disease treated with transmyocardial revascularization in combination with autologous stem cell therapy.</p> <p>Methods</p> <p&g...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-09-01
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| Series: | BMC Cardiovascular Disorders |
| Online Access: | http://www.biomedcentral.com/1471-2261/10/42 |
| _version_ | 1811282444821725184 |
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| author | Caballero Paloma Olivera MariaJose Aguado Beatriz Alegre Adrian Álvarez Pablo Allen Keith B Reyes Guillermo Rodríguez JoseLuis Duarte Juan |
| author_facet | Caballero Paloma Olivera MariaJose Aguado Beatriz Alegre Adrian Álvarez Pablo Allen Keith B Reyes Guillermo Rodríguez JoseLuis Duarte Juan |
| author_sort | Caballero Paloma |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>To evaluate the midterm results of patients with angina and diffuse coronary artery disease treated with transmyocardial revascularization in combination with autologous stem cell therapy.</p> <p>Methods</p> <p>Nineteen patients with diffuse coronary artery disease and medically refractory class III/IV angina were evaluated between June 2007 and December 2009 for sole therapy TMR combined with intramyocardial injection of concentrated stem cells. At the time of surgery, autologous bone marrow (120cc) was aspirated from the iliac crest. A cardiac MRI and an isotopic test were performed before and after the procedure. Follow-up was performed by personal interview.</p> <p>Results</p> <p>There were no perioperative adverse events including no arrhythmias. Mean number of laser channels was 20 and the mean total number of intramyocardially injected cells per milliliter were: total mononuclear cells(83.6 × 10<sup>6</sup>), CD34+ cells(0.6 × 10<sup>6</sup>), and CD133+ cells(0.34 × 10<sup>6</sup>). At 12 months mean follow-up average angina class was significantly improved (3.4 ± 0.5 vs 1.4 ± 0.6; p = 0.004). In addition, monthly cardiovascular medication usage was significantly decreased (348 ± 118 vs. 201 ± 92; p = 0.001). At six months follow up there was a reduction in the number of cardiac hospital readmissions (2.9 ± 2.3 vs. 0.5 ± 0.8; p < 0.001). MRI showed no alterations regarding LV volumes and a 3% improvement regarding ejection fraction.</p> <p>Conclusions</p> <p>The stem cell isolator efficiently concentrated autologous bone marrow derived stem cells while the TMR/stem cell combination delivery device worked uneventfully. An improvement in clinical status was noticed in the midterm follow-up. Images test showed no morphological alterations in the left ventricle after the procedure.</p> |
| first_indexed | 2024-04-13T01:52:48Z |
| format | Article |
| id | doaj.art-5e13a835163b40c6970935ce864bb238 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-13T01:52:48Z |
| publishDate | 2010-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-5e13a835163b40c6970935ce864bb2382022-12-22T03:07:50ZengBMCBMC Cardiovascular Disorders1471-22612010-09-011014210.1186/1471-2261-10-42Mid term results after bone marrow laser revascularization for treating refractory anginaCaballero PalomaOlivera MariaJoseAguado BeatrizAlegre AdrianÁlvarez PabloAllen Keith BReyes GuillermoRodríguez JoseLuisDuarte Juan<p>Abstract</p> <p>Background</p> <p>To evaluate the midterm results of patients with angina and diffuse coronary artery disease treated with transmyocardial revascularization in combination with autologous stem cell therapy.</p> <p>Methods</p> <p>Nineteen patients with diffuse coronary artery disease and medically refractory class III/IV angina were evaluated between June 2007 and December 2009 for sole therapy TMR combined with intramyocardial injection of concentrated stem cells. At the time of surgery, autologous bone marrow (120cc) was aspirated from the iliac crest. A cardiac MRI and an isotopic test were performed before and after the procedure. Follow-up was performed by personal interview.</p> <p>Results</p> <p>There were no perioperative adverse events including no arrhythmias. Mean number of laser channels was 20 and the mean total number of intramyocardially injected cells per milliliter were: total mononuclear cells(83.6 × 10<sup>6</sup>), CD34+ cells(0.6 × 10<sup>6</sup>), and CD133+ cells(0.34 × 10<sup>6</sup>). At 12 months mean follow-up average angina class was significantly improved (3.4 ± 0.5 vs 1.4 ± 0.6; p = 0.004). In addition, monthly cardiovascular medication usage was significantly decreased (348 ± 118 vs. 201 ± 92; p = 0.001). At six months follow up there was a reduction in the number of cardiac hospital readmissions (2.9 ± 2.3 vs. 0.5 ± 0.8; p < 0.001). MRI showed no alterations regarding LV volumes and a 3% improvement regarding ejection fraction.</p> <p>Conclusions</p> <p>The stem cell isolator efficiently concentrated autologous bone marrow derived stem cells while the TMR/stem cell combination delivery device worked uneventfully. An improvement in clinical status was noticed in the midterm follow-up. Images test showed no morphological alterations in the left ventricle after the procedure.</p>http://www.biomedcentral.com/1471-2261/10/42 |
| spellingShingle | Caballero Paloma Olivera MariaJose Aguado Beatriz Alegre Adrian Álvarez Pablo Allen Keith B Reyes Guillermo Rodríguez JoseLuis Duarte Juan Mid term results after bone marrow laser revascularization for treating refractory angina BMC Cardiovascular Disorders |
| title | Mid term results after bone marrow laser revascularization for treating refractory angina |
| title_full | Mid term results after bone marrow laser revascularization for treating refractory angina |
| title_fullStr | Mid term results after bone marrow laser revascularization for treating refractory angina |
| title_full_unstemmed | Mid term results after bone marrow laser revascularization for treating refractory angina |
| title_short | Mid term results after bone marrow laser revascularization for treating refractory angina |
| title_sort | mid term results after bone marrow laser revascularization for treating refractory angina |
| url | http://www.biomedcentral.com/1471-2261/10/42 |
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