Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?
An impaired intestinal barrier function can be detrimental to the host as it may allow the translocation of luminal antigens and toxins into the subepithelial tissue and bloodstream. In turn, this may cause local and systemic immune responses and lead to the development of pathologies. In vitro and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235228952300067X |
| _version_ | 1797405399450648576 |
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| author | Danique La Torre Lukas Van Oudenhove Tim Vanuytsel Kristin Verbeke |
| author_facet | Danique La Torre Lukas Van Oudenhove Tim Vanuytsel Kristin Verbeke |
| author_sort | Danique La Torre |
| collection | DOAJ |
| description | An impaired intestinal barrier function can be detrimental to the host as it may allow the translocation of luminal antigens and toxins into the subepithelial tissue and bloodstream. In turn, this may cause local and systemic immune responses and lead to the development of pathologies. In vitro and animal studies strongly suggest that psychosocial stress is one of the factors that can increase intestinal permeability via mast-cell dependent mechanisms. Remarkably, studies have not been able to yield unequivocal evidence that such relation between stress and intestinal permeability also exists in (healthy) humans. In the current Review, we discuss the mechanisms that are involved in stress-induced intestinal permeability changes and postulate factors that influence these alterations and that may explain the translational difficulties from in vitro and animal to human studies. As human research differs highly from animal research in the extent to which stress can be applied and intestinal permeability can be measured, it remains difficult to draw conclusions about the presence of a relation between stress and intestinal permeability in (healthy) humans. Future studies should bear in mind these difficulties, and more research into in vivo methods to assess intestinal permeability are warranted. |
| first_indexed | 2024-03-09T03:09:52Z |
| format | Article |
| id | doaj.art-5e162b9d6801434fab04e79588ef2af6 |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-03-09T03:09:52Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-5e162b9d6801434fab04e79588ef2af62023-12-04T05:23:00ZengElsevierNeurobiology of Stress2352-28952023-11-0127100579Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence?Danique La Torre0Lukas Van Oudenhove1Tim Vanuytsel2Kristin Verbeke3Translational Research Center in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Faculty of Medicine, KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, BelgiumTranslational Research Center in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Faculty of Medicine, KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, Belgium; Cognitive and Affective Neuroscience Lab, Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH, USATranslational Research Center in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Faculty of Medicine, KU Leuven, Leuven, Belgium; Division of Gastroenterology and Hepatology, Leuven University Hospital, Leuven, BelgiumTranslational Research Center in Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, Faculty of Medicine, KU Leuven, Leuven, Belgium; Corresponding author. Herestraat 49 O&N-1, Box 701, 3000, Leuven, Belgium.An impaired intestinal barrier function can be detrimental to the host as it may allow the translocation of luminal antigens and toxins into the subepithelial tissue and bloodstream. In turn, this may cause local and systemic immune responses and lead to the development of pathologies. In vitro and animal studies strongly suggest that psychosocial stress is one of the factors that can increase intestinal permeability via mast-cell dependent mechanisms. Remarkably, studies have not been able to yield unequivocal evidence that such relation between stress and intestinal permeability also exists in (healthy) humans. In the current Review, we discuss the mechanisms that are involved in stress-induced intestinal permeability changes and postulate factors that influence these alterations and that may explain the translational difficulties from in vitro and animal to human studies. As human research differs highly from animal research in the extent to which stress can be applied and intestinal permeability can be measured, it remains difficult to draw conclusions about the presence of a relation between stress and intestinal permeability in (healthy) humans. Future studies should bear in mind these difficulties, and more research into in vivo methods to assess intestinal permeability are warranted.http://www.sciencedirect.com/science/article/pii/S235228952300067XPsychosocial stressIntestinal permeabilityCortisolCRHMast cells |
| spellingShingle | Danique La Torre Lukas Van Oudenhove Tim Vanuytsel Kristin Verbeke Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? Neurobiology of Stress Psychosocial stress Intestinal permeability Cortisol CRH Mast cells |
| title | Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? |
| title_full | Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? |
| title_fullStr | Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? |
| title_full_unstemmed | Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? |
| title_short | Psychosocial stress-induced intestinal permeability in healthy humans: What is the evidence? |
| title_sort | psychosocial stress induced intestinal permeability in healthy humans what is the evidence |
| topic | Psychosocial stress Intestinal permeability Cortisol CRH Mast cells |
| url | http://www.sciencedirect.com/science/article/pii/S235228952300067X |
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