Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

B cell lymphoma 2 (BCL-2) family proteins are involved in the mitochondrial apoptotic pathway and are key modulators of cellular lifespan, which is dysregulated during human immunodeficiency virus type 1 (HIV-1) and other viral infections, thereby increasing the lifespan of cells harboring virus, in...

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Bibliographic Details
Main Authors: Monica D. Reece, Colin Song, Sarah C. Hancock, Susan Pereira Ribeiro, Deanna A. Kulpa, Christina Gavegnano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
HIV-1
Jak Stat
cancer
Bcl-2
inflammation
HIV reservoir
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1033672/full

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