Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical Study
Background: Hepatotoxicity is one of the inevitable side effects of long term use of medicines in many different disorders, chronic use of alcohol and in certain infectious disorders. Even though there are few effective drugs to treat such hepatotoxicity, mortality due to hepatotoxicity is incre...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5116/9459_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh).pdf |
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| author | Suhani Sumalatha K Shridhar R Pai Nitesh Kumar Kumar MR Bhat |
| author_facet | Suhani Sumalatha K Shridhar R Pai Nitesh Kumar Kumar MR Bhat |
| author_sort | Suhani Sumalatha |
| collection | DOAJ |
| description | Background: Hepatotoxicity is one of the inevitable side effects
of long term use of medicines in many different disorders,
chronic use of alcohol and in certain infectious disorders. Even
though there are few effective drugs to treat such hepatotoxicity,
mortality due to hepatotoxicity is increasing day by day.
Therefore, in search of alternative and more effective medicine
we found that Caesalpinia bonduc (CB), a shrub grows in hotter
places of south Asia has been effectively used to treat such
hepatotoxicity in folk medicine.
Aim: Aim of the study is to scientifically evaluate the
hepatoprotective nature of aqueous extract of CB using Carbon
tetrachloride(CCl4
) induced hepatotoxic rat model.
Materials and Methods and Result: Elevated levels of
blood ALT, AST and ALT enzymes were found in CCl4
induced
hepatotoxic rat models. Treating these animals with CB either
prior or after the induction of hepatotoxicity, shows significant
decrease in the levels of ALP, AST, and ALT in their blood in
comparison with the untreated hepatotoxic group. Additionally,
histologically, hepatotoxic rats show necrotic changes &
vacuolation in their hepatocytes, altered hepatic architecture and
congested hepatic sinusoids. However, such histopathological
adverse changes were minimized when these animals treated
with CB.
Conclusion: Results of the present study indicate that CB acts
as both preventive and curative hepatoprotector. |
| first_indexed | 2024-12-10T12:32:07Z |
| format | Article |
| id | doaj.art-5e16463e3e994bdd97f2e44dabc13c97 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T12:32:07Z |
| publishDate | 2014-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-5e16463e3e994bdd97f2e44dabc13c972022-12-22T01:48:48ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-11-01811HF05HF0710.7860/JCDR/2014/9459.5116Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical StudySuhani Sumalatha0K Shridhar R Pai1Nitesh Kumar2Kumar MR Bhat3Senior Grade Lecturer, Department of Anatomy, Kasturba Medical College, Manipal University, Manipal, India.Professor, Department of Pharmacology, Manipal College of Pharmacy and Pharmaceutical Sciences, Manipal University, Manipal, India.Assistant Professor, Department of Pharmacology, Manipal College of Pharmacy and Pharmaceutical Sciences, Manipal University, Manipal, India.Additional Professor, Department of Anatomy, Manipal College of Pharmacy and Pharmaceutical Sciences, Manipal University, Manipal, India.Background: Hepatotoxicity is one of the inevitable side effects of long term use of medicines in many different disorders, chronic use of alcohol and in certain infectious disorders. Even though there are few effective drugs to treat such hepatotoxicity, mortality due to hepatotoxicity is increasing day by day. Therefore, in search of alternative and more effective medicine we found that Caesalpinia bonduc (CB), a shrub grows in hotter places of south Asia has been effectively used to treat such hepatotoxicity in folk medicine. Aim: Aim of the study is to scientifically evaluate the hepatoprotective nature of aqueous extract of CB using Carbon tetrachloride(CCl4 ) induced hepatotoxic rat model. Materials and Methods and Result: Elevated levels of blood ALT, AST and ALT enzymes were found in CCl4 induced hepatotoxic rat models. Treating these animals with CB either prior or after the induction of hepatotoxicity, shows significant decrease in the levels of ALP, AST, and ALT in their blood in comparison with the untreated hepatotoxic group. Additionally, histologically, hepatotoxic rats show necrotic changes & vacuolation in their hepatocytes, altered hepatic architecture and congested hepatic sinusoids. However, such histopathological adverse changes were minimized when these animals treated with CB. Conclusion: Results of the present study indicate that CB acts as both preventive and curative hepatoprotector.https://jcdr.net/articles/PDF/5116/9459_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh).pdfcaesalpinia bonducccl4hepatoprotection |
| spellingShingle | Suhani Sumalatha K Shridhar R Pai Nitesh Kumar Kumar MR Bhat Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical Study Journal of Clinical and Diagnostic Research caesalpinia bonduc ccl4 hepatoprotection |
| title | Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical Study |
| title_full | Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical Study |
| title_fullStr | Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical Study |
| title_full_unstemmed | Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical Study |
| title_short | Hepatoprotective Role of Caesalpinia bonduc: A Histopathological and Biochemical Study |
| title_sort | hepatoprotective role of caesalpinia bonduc a histopathological and biochemical study |
| topic | caesalpinia bonduc ccl4 hepatoprotection |
| url | https://jcdr.net/articles/PDF/5116/9459_CE(Ra)_F(Sh)_PF1(PAK)_PFA(Sh).pdf |
| work_keys_str_mv | AT suhanisumalatha hepatoprotectiveroleofcaesalpiniabonducahistopathologicalandbiochemicalstudy AT kshridharrpai hepatoprotectiveroleofcaesalpiniabonducahistopathologicalandbiochemicalstudy AT niteshkumar hepatoprotectiveroleofcaesalpiniabonducahistopathologicalandbiochemicalstudy AT kumarmrbhat hepatoprotectiveroleofcaesalpiniabonducahistopathologicalandbiochemicalstudy |