Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentration
Abstract Objectives Endocrinal variations within an individual impact the electrolyte composition, pH, and flow‐rate (FR) of saliva. The aim of this study was to evaluate the gender‐specific differences and the effect of combined estrogen‐progestin oral contraceptives (COCs) on FR, pH, and electroly...
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| Format: | Article |
| Language: | English |
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Wiley
2024-02-01
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| Series: | Clinical and Experimental Dental Research |
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| Online Access: | https://doi.org/10.1002/cre2.800 |
| _version_ | 1797316387700473856 |
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| author | Angela Rovera Paul Anderson |
| author_facet | Angela Rovera Paul Anderson |
| author_sort | Angela Rovera |
| collection | DOAJ |
| description | Abstract Objectives Endocrinal variations within an individual impact the electrolyte composition, pH, and flow‐rate (FR) of saliva. The aim of this study was to evaluate the gender‐specific differences and the effect of combined estrogen‐progestin oral contraceptives (COCs) on FR, pH, and electrolyte concentrations in the parotid saliva (PS) of a group of healthy adults. Material and Methods Stimulated PS was collected from 20 healthy adults using a Lashley cup; 11 males, 8 females, and 1 female undertaking combined contraceptive therapy (levonorgestrel/ethinyloestradiol 0.1 mg + 0.02 mg). FR and pH were recorded for each saliva sample. Electrolytes concentrations (Na+, Ca2+, K+, Mg2+) were measured using inductively coupled plasma optical emission spectrometer (ICP‐OES). Statistical analysis was performed, and the significance level was set at p < .05. Results PS FR varied from 0.13 to 0.42 mL/min in females not taking any medication and from 0.08 to 0.5 mL/min in males not taking any medication. PS pH of females and males not taking any medication ranged from 6.23 to 7.50 and from 6.15 to 7.55. PS pH and FR of the female taking COCs were 6.5 and 0.1 mL/min. PS pH, FR, and electrolytes concentrations (Ca2+, Na+, K+, Mg2+) were not statistically significantly different between females and males not taking any medication. PS concentrations of Ca2+ and Na+ were significantly higher in the females taking COCs than in the females not taking any medication. Whereas, concentrations of K+ and Mg2+ did not differ significantly between the females taking COCs and the females not taking any medication. Conclusions There are no significant gender‐specific differences in PS flow rate, pH, and electrolyte concentrations of Na+, Ca2+, Mg2+, and K+. Combined hormonal oral contraceptive has a significant effect on PS flow rate, pH, Ca2+, and Na+ concentrations. Whereas the PS concentration of K+ and Mg2+ are not influenced by COCs. These results warrant further investigation. |
| first_indexed | 2024-03-08T03:17:40Z |
| format | Article |
| id | doaj.art-5e16803dcd7647369590b3370cc4f7ee |
| institution | Directory Open Access Journal |
| issn | 2057-4347 |
| language | English |
| last_indexed | 2024-03-08T03:17:40Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Experimental Dental Research |
| spelling | doaj.art-5e16803dcd7647369590b3370cc4f7ee2024-02-12T14:56:39ZengWileyClinical and Experimental Dental Research2057-43472024-02-01101n/an/a10.1002/cre2.800Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentrationAngela Rovera0Paul Anderson1Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry Queen Mary University of London London UKDental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry Queen Mary University of London London UKAbstract Objectives Endocrinal variations within an individual impact the electrolyte composition, pH, and flow‐rate (FR) of saliva. The aim of this study was to evaluate the gender‐specific differences and the effect of combined estrogen‐progestin oral contraceptives (COCs) on FR, pH, and electrolyte concentrations in the parotid saliva (PS) of a group of healthy adults. Material and Methods Stimulated PS was collected from 20 healthy adults using a Lashley cup; 11 males, 8 females, and 1 female undertaking combined contraceptive therapy (levonorgestrel/ethinyloestradiol 0.1 mg + 0.02 mg). FR and pH were recorded for each saliva sample. Electrolytes concentrations (Na+, Ca2+, K+, Mg2+) were measured using inductively coupled plasma optical emission spectrometer (ICP‐OES). Statistical analysis was performed, and the significance level was set at p < .05. Results PS FR varied from 0.13 to 0.42 mL/min in females not taking any medication and from 0.08 to 0.5 mL/min in males not taking any medication. PS pH of females and males not taking any medication ranged from 6.23 to 7.50 and from 6.15 to 7.55. PS pH and FR of the female taking COCs were 6.5 and 0.1 mL/min. PS pH, FR, and electrolytes concentrations (Ca2+, Na+, K+, Mg2+) were not statistically significantly different between females and males not taking any medication. PS concentrations of Ca2+ and Na+ were significantly higher in the females taking COCs than in the females not taking any medication. Whereas, concentrations of K+ and Mg2+ did not differ significantly between the females taking COCs and the females not taking any medication. Conclusions There are no significant gender‐specific differences in PS flow rate, pH, and electrolyte concentrations of Na+, Ca2+, Mg2+, and K+. Combined hormonal oral contraceptive has a significant effect on PS flow rate, pH, Ca2+, and Na+ concentrations. Whereas the PS concentration of K+ and Mg2+ are not influenced by COCs. These results warrant further investigation.https://doi.org/10.1002/cre2.800diagnosticsoral contraceptiveparotid glandsaliva |
| spellingShingle | Angela Rovera Paul Anderson Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentration Clinical and Experimental Dental Research diagnostics oral contraceptive parotid gland saliva |
| title | Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentration |
| title_full | Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentration |
| title_fullStr | Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentration |
| title_full_unstemmed | Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentration |
| title_short | Influence of gender and combined estrogen–progestin oral contraceptive on parotid saliva flow rate, pH, and electrolytes concentration |
| title_sort | influence of gender and combined estrogen progestin oral contraceptive on parotid saliva flow rate ph and electrolytes concentration |
| topic | diagnostics oral contraceptive parotid gland saliva |
| url | https://doi.org/10.1002/cre2.800 |
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