Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis

Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis

The inflammatory response induced by fine particulate matter (PM2.5), a common class of air pollutants, is an important trigger for the development of pulmonary fibrosis. However, the specific mechanisms responsible for this phenomenon are yet to be fully understood. To investigate the mechanisms be...

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Bibliographic Details
Main Authors: Siyu Yang, Yaochuan Sun, Yajun Luo, Yingyi Liu, Mengyu Jiang, Jiayou Li, Qibing Zhang, Jun Bai
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PM2.5
DNA methylation
Pulmonary fibrosis
PPARG
5-Azacytidine；inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132400143X

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