Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study
A clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat wer...
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MDPI AG
2021-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/2/463 |
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| author | Adriano Costa de Camargo Anna Paula de Souza Silva Jackeline Cintra Soares Severino Matias de Alencar Cíntia Ladeira Handa Karina Silva Cordeiro Marcela Souza Figueira Geni R. Sampaio Elizabeth A. F. S. Torres Fereidoon Shahidi Andrés R. Schwember |
| author_facet | Adriano Costa de Camargo Anna Paula de Souza Silva Jackeline Cintra Soares Severino Matias de Alencar Cíntia Ladeira Handa Karina Silva Cordeiro Marcela Souza Figueira Geni R. Sampaio Elizabeth A. F. S. Torres Fereidoon Shahidi Andrés R. Schwember |
| author_sort | Adriano Costa de Camargo |
| collection | DOAJ |
| description | A clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat were evaluated in this contribution. The highest recovery of phenolics was achieved using aqueous acetone (50:50, <i>v/v</i>), as verified by multi-response optimization, thus showing that phenolics could be largely underestimated by employing an inappropriate extraction. The concentration of derivatives of apigenin, the main phenolics present, ranged from 63.5 to 80.7%, as evaluated by LC–ESI-QTOF-MS. Phenolics from the breeding line 98 exhibited the highest ability in scavenging peroxyl radicals, reducing power as well as in terms of inhibition of pancreatic lipase activity, a key enzyme regulating the absorption of triacylglycerols. In contrast, none of the samples exhibited a significant anti-diabetic potential. Despite their high concentration compared to that of phenolic acids, results of this work do not support a significant antioxidant and pancreatic lipase inhibitory effect of durum wheat flavonoids. Therefore, breeding programs and animal and/or human trials related to the effect of durum wheat flavonoids on oxidative stress and absorption of triacylglycerols are discouraged at this point. |
| first_indexed | 2024-03-09T04:31:45Z |
| format | Article |
| id | doaj.art-5e1eac2be5474517b7420c4d7687244c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T04:31:45Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-5e1eac2be5474517b7420c4d7687244c2023-12-03T13:34:01ZengMDPI AGMolecules1420-30492021-01-0126246310.3390/molecules26020463Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective StudyAdriano Costa de Camargo0Anna Paula de Souza Silva1Jackeline Cintra Soares2Severino Matias de Alencar3Cíntia Ladeira Handa4Karina Silva Cordeiro5Marcela Souza Figueira6Geni R. Sampaio7Elizabeth A. F. S. Torres8Fereidoon Shahidi9Andrés R. Schwember10Laboratory of Antioxidants, Nutrition and Food Technology Institute, University of Chile, Santiago 7830490, ChileDepartament of Agri-Food Industry, Food & Nutrition, “Luiz de Queiroz” College of Agriculture, University of São Paulo, P.O. Box 9, Piracicaba, SP CEP 13418-900, BrazilDepartament of Agri-Food Industry, Food & Nutrition, “Luiz de Queiroz” College of Agriculture, University of São Paulo, P.O. Box 9, Piracicaba, SP CEP 13418-900, BrazilDepartament of Agri-Food Industry, Food & Nutrition, “Luiz de Queiroz” College of Agriculture, University of São Paulo, P.O. Box 9, Piracicaba, SP CEP 13418-900, BrazilMinas Gerais State University, R. Ver. Geraldo Moisés da Silva 308-434, Ituiutaba, MG CEP 38302-182, BrazilDepartment of Nutrition, School of Public Health, University of São Paulo, 715 Dr. Arnaldo Avenue, São Paulo, SP CEP 01246-904, BrazilDepartment of Nutrition, School of Public Health, University of São Paulo, 715 Dr. Arnaldo Avenue, São Paulo, SP CEP 01246-904, BrazilDepartment of Nutrition, School of Public Health, University of São Paulo, 715 Dr. Arnaldo Avenue, São Paulo, SP CEP 01246-904, BrazilDepartment of Nutrition, School of Public Health, University of São Paulo, 715 Dr. Arnaldo Avenue, São Paulo, SP CEP 01246-904, BrazilDepartment of Biochemistry, Memorial University of Newfoundland, St. John’s, NL A1B 3X9, CanadaDepartamento de Ciencias Vegetales, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile, Santiago 7830490, ChileA clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat were evaluated in this contribution. The highest recovery of phenolics was achieved using aqueous acetone (50:50, <i>v/v</i>), as verified by multi-response optimization, thus showing that phenolics could be largely underestimated by employing an inappropriate extraction. The concentration of derivatives of apigenin, the main phenolics present, ranged from 63.5 to 80.7%, as evaluated by LC–ESI-QTOF-MS. Phenolics from the breeding line 98 exhibited the highest ability in scavenging peroxyl radicals, reducing power as well as in terms of inhibition of pancreatic lipase activity, a key enzyme regulating the absorption of triacylglycerols. In contrast, none of the samples exhibited a significant anti-diabetic potential. Despite their high concentration compared to that of phenolic acids, results of this work do not support a significant antioxidant and pancreatic lipase inhibitory effect of durum wheat flavonoids. Therefore, breeding programs and animal and/or human trials related to the effect of durum wheat flavonoids on oxidative stress and absorption of triacylglycerols are discouraged at this point.https://www.mdpi.com/1420-3049/26/2/463<i>Triticum turgidum</i> L. var. <i>durum</i>surface response methodologyLC–ESI-QTOF-MSantiradical activitypancreatic lipaseobesity |
| spellingShingle | Adriano Costa de Camargo Anna Paula de Souza Silva Jackeline Cintra Soares Severino Matias de Alencar Cíntia Ladeira Handa Karina Silva Cordeiro Marcela Souza Figueira Geni R. Sampaio Elizabeth A. F. S. Torres Fereidoon Shahidi Andrés R. Schwember Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study Molecules <i>Triticum turgidum</i> L. var. <i>durum</i> surface response methodology LC–ESI-QTOF-MS antiradical activity pancreatic lipase obesity |
| title | Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study |
| title_full | Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study |
| title_fullStr | Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study |
| title_full_unstemmed | Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study |
| title_short | Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study |
| title_sort | do flavonoids from durum wheat contribute to its bioactive properties a prospective study |
| topic | <i>Triticum turgidum</i> L. var. <i>durum</i> surface response methodology LC–ESI-QTOF-MS antiradical activity pancreatic lipase obesity |
| url | https://www.mdpi.com/1420-3049/26/2/463 |
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