Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells

Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells

Controlling transgene expression through an externally administered inductor is envisioned as a potent strategy to improve safety and efficacy of gene therapy approaches. Generally, inducible ON systems require a chimeric transcription factor (transactivator) that becomes activated by an inductor, w...

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Bibliographic Details
Main Authors: María Tristán-Manzano, Noelia Maldonado-Pérez, Pedro Justicia-Lirio, Marina Cortijo-Gutierréz, Pablo Tristán-Ramos, Carlos Blanco-Benítez, Kristina Pavlovic, Araceli Aguilar-González, Pilar Muñoz, Francisco J. Molina-Estevez, Valerie Griesche, Juan Antonio Marchal, Sara R. Heras, Karim Benabdellah, Francisco Martin
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
gene therapy
advance therapy medicinal products
externally controlled
inducible
doxycycline
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312300077X

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