Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles

Unbiased genetic screens implicated a number of uncharacterized genes in hearing loss, suggesting some biological processes required for auditory function remain unexplored. Loss of Kiaa1024L/Minar2, a previously understudied gene, caused deafness in mice, but how it functioned in the hearing was un...

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Bibliographic Details
Main Authors: Ge Gao, Shuyu Guo, Quan Zhang, Hefei Zhang, Cuizhen Zhang, Gang Peng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-11-01
Series:eLife
Subjects:
hearing
hair cell
hair bundle
cholesterol
apical membrane
Ubtor
Online Access:https://elifesciences.org/articles/80865

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