| Summary: | <i>Starmerella bacillaris</i> is often isolated from environments associated with grape and winemaking. <i>S. bacillaris</i> has many beneficial properties, including the ability to improve the flavor of wine, the production of beneficial metabolites, and the ability to biocontrol. <i>S. bacillaris</i> CC-PT4 (CGMCC No. 23573) was isolated from grape and can inhibit methicillin-resistant <i>Staphylococcus aureus</i> and adaptability to harsh environments. In this paper, the whole genome of <i>S. bacillaris</i> CC-PT4 was sequenced and bioinformatics analyses were performed. The <i>S. bacillaris</i> CC-PT4 genome was finally assembled into five scaffolds with a genome size of 9.45 Mb and a GC content of 39.5%. It was predicted that the strain contained 4150 protein-coding genes, of which two genes encoded killer toxin and one gene encoded lysostaphin. It also contains genes encoding F1F0-ATPases, Na(+)/H(+) antiporter, cation/H(+) antiporter, ATP-dependent bile acid permease, major facilitator superfamily (MFS) antiporters, and stress response protein, which help <i>S. bacillaris</i> CC-PT4 adapt to bile, acid, and other stressful environments. Proteins related to flocculation and adhesion have also been identified in the <i>S. bacillaris</i> CC-PT4 genome. Predicted by antiSMASH, two secondary metabolite biosynthesis gene clusters were found, and the synthesized metabolites may have antimicrobial effects. Furthermore, <i>S. bacillaris</i> CC-PT4 carried genes associated with pathogenicity and drug resistance. Overall, the whole genome sequencing and analysis of <i>S. bacillaris</i> CC-PT4 in this study provide valuable information for understanding the biological characteristics and further development of this strain.
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