Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group
Endometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.805613/full |
| _version_ | 1828923404120489984 |
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| author | Gian Franco Zannoni Gian Franco Zannoni Emma Bragantini Francesca Castiglione Matteo Fassan Giancarlo Troncone Frediano Inzani Anna Pesci Angela Santoro Filippo Fraggetta Filippo Fraggetta |
| author_facet | Gian Franco Zannoni Gian Franco Zannoni Emma Bragantini Francesca Castiglione Matteo Fassan Giancarlo Troncone Frediano Inzani Anna Pesci Angela Santoro Filippo Fraggetta Filippo Fraggetta |
| author_sort | Gian Franco Zannoni |
| collection | DOAJ |
| description | Endometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications of the proposed new histomolecular classification system for ECs. In view of the substantial genetic and morphological heterogeneity in ECs, both classical pthological parameters and molecular classifiers have to be integrated in the pathology report. This review will focus on the most commonly adopted immunohistochemical and molecular biomarkers in daily clinical characterization of EC, referring to the most recent published recommendations, guidelines, and expert opinions. |
| first_indexed | 2024-12-13T22:37:38Z |
| format | Article |
| id | doaj.art-5e276f51ce8c481f86a789794755ea0c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-13T22:37:38Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5e276f51ce8c481f86a789794755ea0c2022-12-21T23:28:56ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.805613805613Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study GroupGian Franco Zannoni0Gian Franco Zannoni1Emma Bragantini2Francesca Castiglione3Matteo Fassan4Giancarlo Troncone5Frediano Inzani6Anna Pesci7Angela Santoro8Filippo Fraggetta9Filippo Fraggetta10Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalyIstituto di Anatomia Patologica, Università Cattolica del Sacro Cuore, Rome, ItalyDepartment of Surgical Pathology, Ospedale S. Chiara, Trento, ItalyHistopathology and Molecular Diagnostics, Careggi University Hospital, Florence, ItalyDepartment of Medicine - DIMED, University of Padova, Padova, ItalyDepartment of Public Health, University of Naples Federico II, Naples, ItalyUnità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalyDepartment of Pathology, Sacred Heart Hospital Don Calabria Negrar, Verona, ItalyUnità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Rome, ItalyPathology Unit, “Cannizzaro” Hospital, Catania, ItalyPathology Unit, “Gravina” Hospital, Caltagirone, ItalyEndometrial carcinoma (EC) is the most common gynecological malignant disease in high-income countries, such as European countries and the USA. The 2020 edition of the World Health Organization (WHO) Classification of Tumors of the Female Genital Tract underlines the important clinical implications of the proposed new histomolecular classification system for ECs. In view of the substantial genetic and morphological heterogeneity in ECs, both classical pthological parameters and molecular classifiers have to be integrated in the pathology report. This review will focus on the most commonly adopted immunohistochemical and molecular biomarkers in daily clinical characterization of EC, referring to the most recent published recommendations, guidelines, and expert opinions.https://www.frontiersin.org/articles/10.3389/fonc.2022.805613/fullendometrial cancerprognostic markershistomolecular classificationpathological guidelinesprognostic stratification |
| spellingShingle | Gian Franco Zannoni Gian Franco Zannoni Emma Bragantini Francesca Castiglione Matteo Fassan Giancarlo Troncone Frediano Inzani Anna Pesci Angela Santoro Filippo Fraggetta Filippo Fraggetta Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group Frontiers in Oncology endometrial cancer prognostic markers histomolecular classification pathological guidelines prognostic stratification |
| title | Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group |
| title_full | Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group |
| title_fullStr | Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group |
| title_full_unstemmed | Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group |
| title_short | Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group |
| title_sort | current prognostic and predictive biomarkers for endometrial cancer in clinical practice recommendations proposal from the italian study group |
| topic | endometrial cancer prognostic markers histomolecular classification pathological guidelines prognostic stratification |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.805613/full |
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