Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences
Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/18/14083 |
| _version_ | 1797579654602686464 |
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| author | Kevin H. Mayo |
| author_facet | Kevin H. Mayo |
| author_sort | Kevin H. Mayo |
| collection | DOAJ |
| description | Extra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions—in particular, cell adhesion and migration—as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the prospect of physiologically important inter-molecular interactions, especially when both molecules are present or co-expressed in the same cellular environment. This review is focused on such protein-protein interactions with chemokines and galectins, the homo- and hetero-oligomeric structures that they can form, and the functional consequences of those paired interactions. |
| first_indexed | 2024-03-10T22:40:17Z |
| format | Article |
| id | doaj.art-5e281943669f413eafdba5783111e957 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T22:40:17Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5e281943669f413eafdba5783111e9572023-11-19T11:07:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-09-0124181408310.3390/ijms241814083Heterologous Interactions with Galectins and Chemokines and Their Functional ConsequencesKevin H. Mayo0Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota Health Sciences Center, 6-155 Jackson Hall, Minneapolis, MN 55455, USAExtra- and intra-cellular activity occurs under the direction of numerous inter-molecular interactions, and in any tissue or cell, molecules are densely packed, thus promoting those molecular interactions. Galectins and chemokines, the focus of this review, are small, protein effector molecules that mediate various cellular functions—in particular, cell adhesion and migration—as well as cell signaling/activation. In the past, researchers have reported that combinations of these (and other) effector molecules act separately, yet sometimes in concert, but nevertheless physically apart and via their individual cell receptors. This view that each effector molecule functions independently of the other limits our thinking about functional versatility and cooperation, and, in turn, ignores the prospect of physiologically important inter-molecular interactions, especially when both molecules are present or co-expressed in the same cellular environment. This review is focused on such protein-protein interactions with chemokines and galectins, the homo- and hetero-oligomeric structures that they can form, and the functional consequences of those paired interactions.https://www.mdpi.com/1422-0067/24/18/14083galectinchemokinestructurefunctionNMRmodeling |
| spellingShingle | Kevin H. Mayo Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences International Journal of Molecular Sciences galectin chemokine structure function NMR modeling |
| title | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
| title_full | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
| title_fullStr | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
| title_full_unstemmed | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
| title_short | Heterologous Interactions with Galectins and Chemokines and Their Functional Consequences |
| title_sort | heterologous interactions with galectins and chemokines and their functional consequences |
| topic | galectin chemokine structure function NMR modeling |
| url | https://www.mdpi.com/1422-0067/24/18/14083 |
| work_keys_str_mv | AT kevinhmayo heterologousinteractionswithgalectinsandchemokinesandtheirfunctionalconsequences |