Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease
ObjectivesLow-beta oscillation (13–20 Hz) has rarely been studied in patients with early-onset Parkinson’s disease (EOPD, age of onset ≤50 years). We aimed to explore the characteristics of low-beta oscillation in the subthalamic nucleus (STN) of patients with EOPD and investigate the differences be...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1114466/full |
| _version_ | 1797904841366831104 |
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| author | Delong Wu Baotian Zhao Hutao Xie Yichen Xu Zixiao Yin Yutong Bai Yutong Bai Yutong Bai Houyou Fan Quan Zhang Defeng Liu Tianqi Hu Yin Jiang Yin Jiang Qi An Xin Zhang Xin Zhang Anchao Yang Anchao Yang Anchao Yang Jianguo Zhang Jianguo Zhang Jianguo Zhang |
| author_facet | Delong Wu Baotian Zhao Hutao Xie Yichen Xu Zixiao Yin Yutong Bai Yutong Bai Yutong Bai Houyou Fan Quan Zhang Defeng Liu Tianqi Hu Yin Jiang Yin Jiang Qi An Xin Zhang Xin Zhang Anchao Yang Anchao Yang Anchao Yang Jianguo Zhang Jianguo Zhang Jianguo Zhang |
| author_sort | Delong Wu |
| collection | DOAJ |
| description | ObjectivesLow-beta oscillation (13–20 Hz) has rarely been studied in patients with early-onset Parkinson’s disease (EOPD, age of onset ≤50 years). We aimed to explore the characteristics of low-beta oscillation in the subthalamic nucleus (STN) of patients with EOPD and investigate the differences between EOPD and late-onset Parkinson’s disease (LOPD).MethodsWe enrolled 31 EOPD and 31 LOPD patients, who were matched using propensity score matching. Patients underwent bilateral STN deep brain stimulation (DBS). Local field potentials were recorded using intraoperative microelectrode recording. We analyzed the low-beta band parameters, including aperiodic/periodic components, beta burst, and phase-amplitude coupling. We compared low-beta band activity between EOPD and LOPD. Correlation analyses were performed between the low-beta parameters and clinical assessment results for each group.ResultsWe found that the EOPD group had lower aperiodic parameters, including offset (p = 0.010) and exponent (p = 0.047). Low-beta burst analysis showed that EOPD patients had significantly higher average burst amplitude (p = 0.016) and longer average burst duration (p = 0.011). Furthermore, EOPD had higher proportion of long burst (500–650 ms, p = 0.008), while LOPD had higher proportion of short burst (200–350 ms, p = 0.007). There was a significant difference in phase-amplitude coupling values between low-beta phase and fast high frequency oscillation (300–460 Hz) amplitude (p = 0.019).ConclusionWe found that low-beta activity in the STN of patients with EOPD had characteristics that varied when compared with LOPD, and provided electrophysiological evidence for different pathological mechanisms between the two types of PD. These differences need to be considered when applying adaptive DBS on patients of different ages. |
| first_indexed | 2024-04-10T09:55:19Z |
| format | Article |
| id | doaj.art-5e28750ad8744ffb8987a01a4278f486 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-10T09:55:19Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5e28750ad8744ffb8987a01a4278f4862023-02-16T12:37:53ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-02-011510.3389/fnagi.2023.11144661114466Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s diseaseDelong Wu0Baotian Zhao1Hutao Xie2Yichen Xu3Zixiao Yin4Yutong Bai5Yutong Bai6Yutong Bai7Houyou Fan8Quan Zhang9Defeng Liu10Tianqi Hu11Yin Jiang12Yin Jiang13Qi An14Xin Zhang15Xin Zhang16Anchao Yang17Anchao Yang18Anchao Yang19Jianguo Zhang20Jianguo Zhang21Jianguo Zhang22Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Neurostimulation, Beijing, ChinaDepartment of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, ChinaObjectivesLow-beta oscillation (13–20 Hz) has rarely been studied in patients with early-onset Parkinson’s disease (EOPD, age of onset ≤50 years). We aimed to explore the characteristics of low-beta oscillation in the subthalamic nucleus (STN) of patients with EOPD and investigate the differences between EOPD and late-onset Parkinson’s disease (LOPD).MethodsWe enrolled 31 EOPD and 31 LOPD patients, who were matched using propensity score matching. Patients underwent bilateral STN deep brain stimulation (DBS). Local field potentials were recorded using intraoperative microelectrode recording. We analyzed the low-beta band parameters, including aperiodic/periodic components, beta burst, and phase-amplitude coupling. We compared low-beta band activity between EOPD and LOPD. Correlation analyses were performed between the low-beta parameters and clinical assessment results for each group.ResultsWe found that the EOPD group had lower aperiodic parameters, including offset (p = 0.010) and exponent (p = 0.047). Low-beta burst analysis showed that EOPD patients had significantly higher average burst amplitude (p = 0.016) and longer average burst duration (p = 0.011). Furthermore, EOPD had higher proportion of long burst (500–650 ms, p = 0.008), while LOPD had higher proportion of short burst (200–350 ms, p = 0.007). There was a significant difference in phase-amplitude coupling values between low-beta phase and fast high frequency oscillation (300–460 Hz) amplitude (p = 0.019).ConclusionWe found that low-beta activity in the STN of patients with EOPD had characteristics that varied when compared with LOPD, and provided electrophysiological evidence for different pathological mechanisms between the two types of PD. These differences need to be considered when applying adaptive DBS on patients of different ages.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1114466/fullParkinson’s diseaseagingsubthalamic nucleusmicroelectrode recordinglocal field potential |
| spellingShingle | Delong Wu Baotian Zhao Hutao Xie Yichen Xu Zixiao Yin Yutong Bai Yutong Bai Yutong Bai Houyou Fan Quan Zhang Defeng Liu Tianqi Hu Yin Jiang Yin Jiang Qi An Xin Zhang Xin Zhang Anchao Yang Anchao Yang Anchao Yang Jianguo Zhang Jianguo Zhang Jianguo Zhang Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease Frontiers in Aging Neuroscience Parkinson’s disease aging subthalamic nucleus microelectrode recording local field potential |
| title | Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease |
| title_full | Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease |
| title_fullStr | Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease |
| title_full_unstemmed | Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease |
| title_short | Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease |
| title_sort | profiling the low beta characteristics of the subthalamic nucleus in early and late onset parkinson s disease |
| topic | Parkinson’s disease aging subthalamic nucleus microelectrode recording local field potential |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1114466/full |
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