Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies
Tunneling nanotubes (TNTs) are thin membrane elongations among the cells that mediate the trafficking of subcellular organelles, biomolecules, and cues. Mesenchymal stem cells (MSCs) receive substantial attention in tissue engineering and regenerative medicine. Many MSCs-based clinical trials are on...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/10/3481 |
| _version_ | 1797567958992551936 |
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| author | Thangavelu Soundara Rajan Agnese Gugliandolo Placido Bramanti Emanuela Mazzon |
| author_facet | Thangavelu Soundara Rajan Agnese Gugliandolo Placido Bramanti Emanuela Mazzon |
| author_sort | Thangavelu Soundara Rajan |
| collection | DOAJ |
| description | Tunneling nanotubes (TNTs) are thin membrane elongations among the cells that mediate the trafficking of subcellular organelles, biomolecules, and cues. Mesenchymal stem cells (MSCs) receive substantial attention in tissue engineering and regenerative medicine. Many MSCs-based clinical trials are ongoing for dreadful diseases including cancer and neurodegenerative diseases. Mitochondrial trafficking through TNTs is one of the mechanisms used by MSCs to repair tissue damage and to promote tissue regeneration. Preclinical studies linked with ischemia, oxidative stress, mitochondrial damage, inflammation, and respiratory illness have demonstrated the therapeutic efficacy of MSCs via TNTs-mediated transfer of mitochondria and other molecules into the injured cells. On the other hand, MSCs-based cancer studies showed that TNTs may modulate chemoresistance in tumor cells as a result of mitochondrial trafficking. In the present review, we discuss the role of TNTs from preclinical studies associated with MSCs treatment. We discuss the impact of TNTs formation between MSCs and cancer cells and emphasize to study the importance of TNTs-mediated MSCs protection in disease models. |
| first_indexed | 2024-03-10T19:49:35Z |
| format | Article |
| id | doaj.art-5e295cadaf6d46e38250042b98f4e0a4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:49:35Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5e295cadaf6d46e38250042b98f4e0a42023-11-20T00:31:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012110348110.3390/ijms21103481Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical StudiesThangavelu Soundara Rajan0Agnese Gugliandolo1Placido Bramanti2Emanuela Mazzon3Department of Biotechnology, School of Life Sciences, Karpagam Academy of Higher Education, Coimbatore 641021, IndiaIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Palermo, Contrada Casazza S.S.113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Palermo, Contrada Casazza S.S.113, 98124 Messina, ItalyIRCCS Centro Neurolesi “Bonino-Pulejo”, Via Palermo, Contrada Casazza S.S.113, 98124 Messina, ItalyTunneling nanotubes (TNTs) are thin membrane elongations among the cells that mediate the trafficking of subcellular organelles, biomolecules, and cues. Mesenchymal stem cells (MSCs) receive substantial attention in tissue engineering and regenerative medicine. Many MSCs-based clinical trials are ongoing for dreadful diseases including cancer and neurodegenerative diseases. Mitochondrial trafficking through TNTs is one of the mechanisms used by MSCs to repair tissue damage and to promote tissue regeneration. Preclinical studies linked with ischemia, oxidative stress, mitochondrial damage, inflammation, and respiratory illness have demonstrated the therapeutic efficacy of MSCs via TNTs-mediated transfer of mitochondria and other molecules into the injured cells. On the other hand, MSCs-based cancer studies showed that TNTs may modulate chemoresistance in tumor cells as a result of mitochondrial trafficking. In the present review, we discuss the role of TNTs from preclinical studies associated with MSCs treatment. We discuss the impact of TNTs formation between MSCs and cancer cells and emphasize to study the importance of TNTs-mediated MSCs protection in disease models.https://www.mdpi.com/1422-0067/21/10/3481tunneling nanotubesmesenchymal stem cellsmitochondriacancer cellspreclinical studies |
| spellingShingle | Thangavelu Soundara Rajan Agnese Gugliandolo Placido Bramanti Emanuela Mazzon Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies International Journal of Molecular Sciences tunneling nanotubes mesenchymal stem cells mitochondria cancer cells preclinical studies |
| title | Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies |
| title_full | Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies |
| title_fullStr | Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies |
| title_full_unstemmed | Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies |
| title_short | Tunneling Nanotubes-Mediated Protection of Mesenchymal Stem Cells: An Update from Preclinical Studies |
| title_sort | tunneling nanotubes mediated protection of mesenchymal stem cells an update from preclinical studies |
| topic | tunneling nanotubes mesenchymal stem cells mitochondria cancer cells preclinical studies |
| url | https://www.mdpi.com/1422-0067/21/10/3481 |
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