The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem
Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in elderly individuals. The current therapeutic management, a combined regimen of poly-chemotherapy and surgery, still remains largely insufficient...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/4/976 |
| _version_ | 1827718618983432192 |
|---|---|
| author | Isabelle Corre Franck Verrecchia Vincent Crenn Francoise Redini Valérie Trichet |
| author_facet | Isabelle Corre Franck Verrecchia Vincent Crenn Francoise Redini Valérie Trichet |
| author_sort | Isabelle Corre |
| collection | DOAJ |
| description | Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in elderly individuals. The current therapeutic management, a combined regimen of poly-chemotherapy and surgery, still remains largely insufficient, as patient survival has not improved in recent decades. Osteosarcomas are very heterogeneous tumors, both at the intra- and inter-tumor level, with no identified driver mutation. Consequently, efforts to improve treatments using targeted therapies have faced this lack of specific osteosarcoma targets. Nevertheless, these tumors are inextricably linked to their local microenvironment, composed of bone, stromal, vascular and immune cells and the osteosarcoma microenvironment is now considered to be essential and supportive for growth and dissemination. This review describes the different actors of the osteosarcoma microenvironment and gives an overview of the past, current, and future strategies of therapy targeting this complex ecosystem, with a focus on the role of extracellular vesicles and on the emergence of multi-kinase inhibitors. |
| first_indexed | 2024-03-10T20:28:03Z |
| format | Article |
| id | doaj.art-5e29aa368b1f4dc89a1dd7e3f7abc70e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T20:28:03Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5e29aa368b1f4dc89a1dd7e3f7abc70e2023-11-19T21:38:55ZengMDPI AGCells2073-44092020-04-019497610.3390/cells9040976The Osteosarcoma Microenvironment: A Complex but Targetable EcosystemIsabelle Corre0Franck Verrecchia1Vincent Crenn2Francoise Redini3Valérie Trichet4INSERM, Nantes University, UMR1238 Phy-Os “Bone Sarcomas and Remodeling of Calcified Tissues”, F-44035 Nantes, FranceINSERM, Nantes University, UMR1238 Phy-Os “Bone Sarcomas and Remodeling of Calcified Tissues”, F-44035 Nantes, FranceINSERM, Nantes University, UMR1238 Phy-Os “Bone Sarcomas and Remodeling of Calcified Tissues”, F-44035 Nantes, FranceINSERM, Nantes University, UMR1238 Phy-Os “Bone Sarcomas and Remodeling of Calcified Tissues”, F-44035 Nantes, FranceINSERM, Nantes University, UMR1238 Phy-Os “Bone Sarcomas and Remodeling of Calcified Tissues”, F-44035 Nantes, FranceOsteosarcomas are the most frequent primary bone sarcomas, affecting mainly children, adolescents, and young adults, and with a second peak of incidence in elderly individuals. The current therapeutic management, a combined regimen of poly-chemotherapy and surgery, still remains largely insufficient, as patient survival has not improved in recent decades. Osteosarcomas are very heterogeneous tumors, both at the intra- and inter-tumor level, with no identified driver mutation. Consequently, efforts to improve treatments using targeted therapies have faced this lack of specific osteosarcoma targets. Nevertheless, these tumors are inextricably linked to their local microenvironment, composed of bone, stromal, vascular and immune cells and the osteosarcoma microenvironment is now considered to be essential and supportive for growth and dissemination. This review describes the different actors of the osteosarcoma microenvironment and gives an overview of the past, current, and future strategies of therapy targeting this complex ecosystem, with a focus on the role of extracellular vesicles and on the emergence of multi-kinase inhibitors.https://www.mdpi.com/2073-4409/9/4/976Osteosarcomamicroenvironmentbonestromal cellsvascular cellstargeted therapies |
| spellingShingle | Isabelle Corre Franck Verrecchia Vincent Crenn Francoise Redini Valérie Trichet The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem Cells Osteosarcoma microenvironment bone stromal cells vascular cells targeted therapies |
| title | The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem |
| title_full | The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem |
| title_fullStr | The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem |
| title_full_unstemmed | The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem |
| title_short | The Osteosarcoma Microenvironment: A Complex but Targetable Ecosystem |
| title_sort | osteosarcoma microenvironment a complex but targetable ecosystem |
| topic | Osteosarcoma microenvironment bone stromal cells vascular cells targeted therapies |
| url | https://www.mdpi.com/2073-4409/9/4/976 |
| work_keys_str_mv | AT isabellecorre theosteosarcomamicroenvironmentacomplexbuttargetableecosystem AT franckverrecchia theosteosarcomamicroenvironmentacomplexbuttargetableecosystem AT vincentcrenn theosteosarcomamicroenvironmentacomplexbuttargetableecosystem AT francoiseredini theosteosarcomamicroenvironmentacomplexbuttargetableecosystem AT valerietrichet theosteosarcomamicroenvironmentacomplexbuttargetableecosystem AT isabellecorre osteosarcomamicroenvironmentacomplexbuttargetableecosystem AT franckverrecchia osteosarcomamicroenvironmentacomplexbuttargetableecosystem AT vincentcrenn osteosarcomamicroenvironmentacomplexbuttargetableecosystem AT francoiseredini osteosarcomamicroenvironmentacomplexbuttargetableecosystem AT valerietrichet osteosarcomamicroenvironmentacomplexbuttargetableecosystem |