Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia
Introduction It has been suggested that dysregulation of sex hormones is associated with schizophrenia. However, obesity and metabolic syndrome are very common between schizophrenic patients, and it can also dysregulate sex hormones so they could act as confounders. Objectives To determine if estr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822018971/type/journal_article |
| _version_ | 1827754654220419072 |
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| author | A. Ruiz-Tristan C. Rivera-Clemente V. Gomez-De-Las-Heras S. Ávila J. Molina |
| author_facet | A. Ruiz-Tristan C. Rivera-Clemente V. Gomez-De-Las-Heras S. Ávila J. Molina |
| author_sort | A. Ruiz-Tristan |
| collection | DOAJ |
| description |
Introduction
It has been suggested that dysregulation of sex hormones is associated with schizophrenia. However, obesity and metabolic syndrome are very common between schizophrenic patients, and it can also dysregulate sex hormones so they could act as confounders.
Objectives
To determine if estradiol and progesterone are abnormally elevated regardless of obesity or metabolic syndrome in men with SCZ.
Methods
We measured serum levels of progesterone and estradiol in 56 schizophrenic male patients at treatment with a depot antipsychotic. Subsequently, we studied the association or independence of our results with obesity or metabolic syndrome by a Chi Square Test.
Results
66.07% of our patients elevated progesterone levels, 19.64% of our patients elevated estradiol levels, and 16.07% of our patients elevated both, progesterone and estradiol, simultaneously. We found no relationship between increased estradiol and / or progesterone with obesity and / or metabolic syndrome.
Conclusions
Estradiol and progesterone are abnormally elevated regardless of obesity and / or metabolic syndrome in male schizophrenic patients on depot treatment.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:52:29Z |
| format | Article |
| id | doaj.art-5e29e0fa1c5c4536937b4b617da64648 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:52:29Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-5e29e0fa1c5c4536937b4b617da646482023-11-17T05:06:20ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S734S73410.1192/j.eurpsy.2022.1897Estradiol and Progesterone as key modulators of central systems implicated in schizophreniaA. Ruiz-Tristan0C. Rivera-Clemente1V. Gomez-De-Las-Heras2S. Ávila3J. Molina4Hospital 12 de Octubre, Villaverde Mental Health Center, Madrid, Spain Hospital 12 de Octubre, Psychiatry, Madrid, SpainHospital 12 de Octubre, Villaverde Mental Health Center, Madrid, SpainHospital 12 de Octubre, Villaverde Mental Health Center, Madrid, Spain Hospital 12 de Octubre, Psychiatry, Madrid, SpainComplutense University of Madrid, Psychiatry, Madrid, SpainHospital 12 de Octubre, Villaverde Mental Health Center, Madrid, Spain Hospital 12 de Octubre, Center For Biological Research In Mental Health (cibersam), Madrid, Spain Hospital 12 de Octubre, Clinical Management Area Of Psychiatry And Mental Health, Madrid, Spain Introduction It has been suggested that dysregulation of sex hormones is associated with schizophrenia. However, obesity and metabolic syndrome are very common between schizophrenic patients, and it can also dysregulate sex hormones so they could act as confounders. Objectives To determine if estradiol and progesterone are abnormally elevated regardless of obesity or metabolic syndrome in men with SCZ. Methods We measured serum levels of progesterone and estradiol in 56 schizophrenic male patients at treatment with a depot antipsychotic. Subsequently, we studied the association or independence of our results with obesity or metabolic syndrome by a Chi Square Test. Results 66.07% of our patients elevated progesterone levels, 19.64% of our patients elevated estradiol levels, and 16.07% of our patients elevated both, progesterone and estradiol, simultaneously. We found no relationship between increased estradiol and / or progesterone with obesity and / or metabolic syndrome. Conclusions Estradiol and progesterone are abnormally elevated regardless of obesity and / or metabolic syndrome in male schizophrenic patients on depot treatment. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822018971/type/journal_articleschizophréniaprogesteroneestradiolendocrinology |
| spellingShingle | A. Ruiz-Tristan C. Rivera-Clemente V. Gomez-De-Las-Heras S. Ávila J. Molina Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia European Psychiatry schizophrénia progesterone estradiol endocrinology |
| title | Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia |
| title_full | Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia |
| title_fullStr | Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia |
| title_full_unstemmed | Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia |
| title_short | Estradiol and Progesterone as key modulators of central systems implicated in schizophrenia |
| title_sort | estradiol and progesterone as key modulators of central systems implicated in schizophrenia |
| topic | schizophrénia progesterone estradiol endocrinology |
| url | https://www.cambridge.org/core/product/identifier/S0924933822018971/type/journal_article |
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