Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives
Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) are specific innate lymphoid cell subsets that are key for the detection and elimination of pathogens and cancer cells. In liver, while they share a number of characteristics, they differ in many features. These include their developm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/9044 |
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| author | Nicolas Jacquelot Cyril Seillet Fernando Souza-Fonseca-Guimaraes Adrian G. Sacher Gabrielle T. Belz Pamela S. Ohashi |
| author_facet | Nicolas Jacquelot Cyril Seillet Fernando Souza-Fonseca-Guimaraes Adrian G. Sacher Gabrielle T. Belz Pamela S. Ohashi |
| author_sort | Nicolas Jacquelot |
| collection | DOAJ |
| description | Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) are specific innate lymphoid cell subsets that are key for the detection and elimination of pathogens and cancer cells. In liver, while they share a number of characteristics, they differ in many features. These include their developmental pathways, tissue distribution, phenotype and functions. NK cells and ILC1 contribute to organ homeostasis through the production of key cytokines and chemokines and the elimination of potential harmful bacteria and viruses. In addition, they are equipped with a wide range of receptors, allowing them to detect “stressed cells’ such as cancer cells. Our understanding of the role of innate lymphoid cells in hepatocellular carcinoma (HCC) is growing owing to the development of mouse models, the progress in immunotherapeutic treatment and the recent use of scRNA sequencing analyses. In this review, we summarize the current understanding of NK cells and ILC1 in hepatocellular carcinoma and discuss future strategies to take advantage of these innate immune cells in anti-tumor immunity. Immunotherapies hold great promise in HCC, and a better understanding of the role and function of NK cells and ILC1 in liver cancer could pave the way for new NK cell and/or ILC1-targeted treatment. |
| first_indexed | 2024-03-10T08:43:51Z |
| format | Article |
| id | doaj.art-5e2a51de24fc49a5a26a604e902eed16 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:43:51Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5e2a51de24fc49a5a26a604e902eed162023-11-22T08:04:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216904410.3390/ijms22169044Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future PerspectivesNicolas Jacquelot0Cyril Seillet1Fernando Souza-Fonseca-Guimaraes2Adrian G. Sacher3Gabrielle T. Belz4Pamela S. Ohashi5Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, CanadaWalter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, AustraliaDiamantina Institute, University of Queensland, 37 Kent Street, Woolloongabba, Brisbane, QLD 4102, AustraliaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, CanadaWalter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, AustraliaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, CanadaNatural killer (NK) cells and type 1 innate lymphoid cells (ILC1) are specific innate lymphoid cell subsets that are key for the detection and elimination of pathogens and cancer cells. In liver, while they share a number of characteristics, they differ in many features. These include their developmental pathways, tissue distribution, phenotype and functions. NK cells and ILC1 contribute to organ homeostasis through the production of key cytokines and chemokines and the elimination of potential harmful bacteria and viruses. In addition, they are equipped with a wide range of receptors, allowing them to detect “stressed cells’ such as cancer cells. Our understanding of the role of innate lymphoid cells in hepatocellular carcinoma (HCC) is growing owing to the development of mouse models, the progress in immunotherapeutic treatment and the recent use of scRNA sequencing analyses. In this review, we summarize the current understanding of NK cells and ILC1 in hepatocellular carcinoma and discuss future strategies to take advantage of these innate immune cells in anti-tumor immunity. Immunotherapies hold great promise in HCC, and a better understanding of the role and function of NK cells and ILC1 in liver cancer could pave the way for new NK cell and/or ILC1-targeted treatment.https://www.mdpi.com/1422-0067/22/16/9044natural killer cellsinnate lymphoid cellsILC1liverhepatocellular carcinomacancer |
| spellingShingle | Nicolas Jacquelot Cyril Seillet Fernando Souza-Fonseca-Guimaraes Adrian G. Sacher Gabrielle T. Belz Pamela S. Ohashi Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives International Journal of Molecular Sciences natural killer cells innate lymphoid cells ILC1 liver hepatocellular carcinoma cancer |
| title | Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives |
| title_full | Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives |
| title_fullStr | Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives |
| title_full_unstemmed | Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives |
| title_short | Natural Killer Cells and Type 1 Innate Lymphoid Cells in Hepatocellular Carcinoma: Current Knowledge and Future Perspectives |
| title_sort | natural killer cells and type 1 innate lymphoid cells in hepatocellular carcinoma current knowledge and future perspectives |
| topic | natural killer cells innate lymphoid cells ILC1 liver hepatocellular carcinoma cancer |
| url | https://www.mdpi.com/1422-0067/22/16/9044 |
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