Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis
Parkinson’s disease is a severe neurodegenerative disorder. Currently, deep brain electrical stimulation (DBS) is the first line of surgical treatment. However, serious neurological impairments such as speech disorders, disturbances of consciousness, and depression after surgery limit the efficacy o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/45/5/284 |
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| author | Hao Meng Jia-Hang Wei Peng-Zheng Yu Jia-Xin Ren Meng-Yao Tang Jun-Yi Sun Xiao-Yu Yan Jing Su |
| author_facet | Hao Meng Jia-Hang Wei Peng-Zheng Yu Jia-Xin Ren Meng-Yao Tang Jun-Yi Sun Xiao-Yu Yan Jing Su |
| author_sort | Hao Meng |
| collection | DOAJ |
| description | Parkinson’s disease is a severe neurodegenerative disorder. Currently, deep brain electrical stimulation (DBS) is the first line of surgical treatment. However, serious neurological impairments such as speech disorders, disturbances of consciousness, and depression after surgery limit the efficacy of treatment. In this review, we summarize the recent experimental and clinical studies that have explored the possible causes of neurological deficits after DBS. Furthermore, we tried to identify clues from oxidative stress and pathological changes in patients that could lead to the activation of microglia and astrocytes in DBS surgical injury. Notably, reliable evidence supports the idea that neuroinflammation is caused by microglia and astrocytes, which may contribute to caspase-1 pathway-mediated neuronal pyroptosis. Finally, existing drugs and treatments may partially ameliorate the loss of neurological function in patients following DBS surgery by exerting neuroprotective effects. |
| first_indexed | 2024-03-11T03:50:42Z |
| format | Article |
| id | doaj.art-5e2a7f82f13c414caf2b3436df7b1583 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-11T03:50:42Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-5e2a7f82f13c414caf2b3436df7b15832023-11-18T00:57:22ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-05-014554480449410.3390/cimb45050284Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and PyroptosisHao Meng0Jia-Hang Wei1Peng-Zheng Yu2Jia-Xin Ren3Meng-Yao Tang4Jun-Yi Sun5Xiao-Yu Yan6Jing Su7Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130021, ChinaParkinson’s disease is a severe neurodegenerative disorder. Currently, deep brain electrical stimulation (DBS) is the first line of surgical treatment. However, serious neurological impairments such as speech disorders, disturbances of consciousness, and depression after surgery limit the efficacy of treatment. In this review, we summarize the recent experimental and clinical studies that have explored the possible causes of neurological deficits after DBS. Furthermore, we tried to identify clues from oxidative stress and pathological changes in patients that could lead to the activation of microglia and astrocytes in DBS surgical injury. Notably, reliable evidence supports the idea that neuroinflammation is caused by microglia and astrocytes, which may contribute to caspase-1 pathway-mediated neuronal pyroptosis. Finally, existing drugs and treatments may partially ameliorate the loss of neurological function in patients following DBS surgery by exerting neuroprotective effects.https://www.mdpi.com/1467-3045/45/5/284Parkinson’s diseaseDBS surgerypyroptosisneuroinflammationneuroprotective |
| spellingShingle | Hao Meng Jia-Hang Wei Peng-Zheng Yu Jia-Xin Ren Meng-Yao Tang Jun-Yi Sun Xiao-Yu Yan Jing Su Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis Current Issues in Molecular Biology Parkinson’s disease DBS surgery pyroptosis neuroinflammation neuroprotective |
| title | Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis |
| title_full | Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis |
| title_fullStr | Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis |
| title_full_unstemmed | Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis |
| title_short | Insights into Advanced Neurological Dysfunction Mechanisms Following DBS Surgery in Parkinson’s Patients: Neuroinflammation and Pyroptosis |
| title_sort | insights into advanced neurological dysfunction mechanisms following dbs surgery in parkinson s patients neuroinflammation and pyroptosis |
| topic | Parkinson’s disease DBS surgery pyroptosis neuroinflammation neuroprotective |
| url | https://www.mdpi.com/1467-3045/45/5/284 |
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