Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC)
Background: This study aimed to assess the association of 18F-Fluorodeoxyglucose positron-emission-tomography (18F-FDG/PET) and DWI imaging parameters from a primary tumor and their correlations with clinicopathological factors. Methods: We retrospectively analyzed primary tumors in 71 patients with...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/847 |
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| author | Omar Freihat Tóth Zoltán Tamas Pinter András Kedves Dávid Sipos Imre Repa Árpád Kovács Cselik Zsolt |
| author_facet | Omar Freihat Tóth Zoltán Tamas Pinter András Kedves Dávid Sipos Imre Repa Árpád Kovács Cselik Zsolt |
| author_sort | Omar Freihat |
| collection | DOAJ |
| description | Background: This study aimed to assess the association of 18F-Fluorodeoxyglucose positron-emission-tomography (18F-FDG/PET) and DWI imaging parameters from a primary tumor and their correlations with clinicopathological factors. Methods: We retrospectively analyzed primary tumors in 71 patients with proven HNC. Primary tumor radiological parameters: DWI and FDG, as well as pathological characteristics were analyzed. Spearman correlation coefficient was used to assess the correlation between DWI and FDG parameters, ANOVA or Kruskal–Wallis, independent sample t-test, Mann–Whitney test, and multiple regression were performed on the clinicopathological features that may affect the 18F- FDG and apparent-diffusion coefficient (ADC) of the tumor. Results: No significant correlations were observed between DWI and any of the 18F-FDG parameters (<i>p</i> > 0.05). SUVmax correlated with N-stages (<i>p</i> = 0.023), TLG and MTV correlated with T-stages (<i>p</i> = 0.006 and <i>p</i> = 0.001), and ADC correlated with tumor grades (<i>p</i> = 0.05). SUVmax was able to differentiate between N+ and N− groups (<i>p</i> = 0.004). Conclusions: Our results revealed a non-significant correlation between the FDG-PET and ADC-MR parameters. FDG-PET-based glucose metabolic and DWI-MR-derived cellularity data may represent different biological aspects of HNC. |
| first_indexed | 2024-03-10T00:05:14Z |
| format | Article |
| id | doaj.art-5e2ad72c53404265b5d43ff08dbc6b2c |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:05:14Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5e2ad72c53404265b5d43ff08dbc6b2c2023-11-23T16:09:40ZengMDPI AGCancers2072-66942022-02-0114384710.3390/cancers14030847Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC)Omar Freihat0Tóth Zoltán1Tamas Pinter2András Kedves3Dávid Sipos4Imre Repa5Árpád Kovács6Cselik Zsolt7Department of Medical Imaging, Faculty of Health Sciences, University of Pécs, 7621 Pécs, HungaryDoctoral School of Health Sciences, University of Pécs, 7621 Pécs, HungaryDr. József Baka Diagnostic, Radiation Oncology, Research and Teaching Center, “Moritz Kaposi” Teaching Hospital, 7400 Kaposvár, HungaryDoctoral School of Health Sciences, University of Pécs, 7621 Pécs, HungaryDepartment of Medical Imaging, Faculty of Health Sciences, University of Pécs, 7621 Pécs, HungaryDoctoral School of Health Sciences, University of Pécs, 7621 Pécs, HungaryDepartment of Medical Imaging, Faculty of Health Sciences, University of Pécs, 7621 Pécs, HungaryDoctoral School of Health Sciences, University of Pécs, 7621 Pécs, HungaryBackground: This study aimed to assess the association of 18F-Fluorodeoxyglucose positron-emission-tomography (18F-FDG/PET) and DWI imaging parameters from a primary tumor and their correlations with clinicopathological factors. Methods: We retrospectively analyzed primary tumors in 71 patients with proven HNC. Primary tumor radiological parameters: DWI and FDG, as well as pathological characteristics were analyzed. Spearman correlation coefficient was used to assess the correlation between DWI and FDG parameters, ANOVA or Kruskal–Wallis, independent sample t-test, Mann–Whitney test, and multiple regression were performed on the clinicopathological features that may affect the 18F- FDG and apparent-diffusion coefficient (ADC) of the tumor. Results: No significant correlations were observed between DWI and any of the 18F-FDG parameters (<i>p</i> > 0.05). SUVmax correlated with N-stages (<i>p</i> = 0.023), TLG and MTV correlated with T-stages (<i>p</i> = 0.006 and <i>p</i> = 0.001), and ADC correlated with tumor grades (<i>p</i> = 0.05). SUVmax was able to differentiate between N+ and N− groups (<i>p</i> = 0.004). Conclusions: Our results revealed a non-significant correlation between the FDG-PET and ADC-MR parameters. FDG-PET-based glucose metabolic and DWI-MR-derived cellularity data may represent different biological aspects of HNC.https://www.mdpi.com/2072-6694/14/3/847diffusion-weighted imagingapparent diffusion coefficienthead and neck squamous cell carcinomaPET/MRIglucose metabolismprimary tumor |
| spellingShingle | Omar Freihat Tóth Zoltán Tamas Pinter András Kedves Dávid Sipos Imre Repa Árpád Kovács Cselik Zsolt Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) Cancers diffusion-weighted imaging apparent diffusion coefficient head and neck squamous cell carcinoma PET/MRI glucose metabolism primary tumor |
| title | Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) |
| title_full | Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) |
| title_fullStr | Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) |
| title_full_unstemmed | Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) |
| title_short | Correlation between Tissue Cellularity and Metabolism Represented by Diffusion-Weighted Imaging (DWI) and 18F-FDG PET/MRI in Head and Neck Cancer (HNC) |
| title_sort | correlation between tissue cellularity and metabolism represented by diffusion weighted imaging dwi and 18f fdg pet mri in head and neck cancer hnc |
| topic | diffusion-weighted imaging apparent diffusion coefficient head and neck squamous cell carcinoma PET/MRI glucose metabolism primary tumor |
| url | https://www.mdpi.com/2072-6694/14/3/847 |
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