Renal disease pathophysiology and treatment: contributions from the rat
The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome engineering now allow us to capitalize on the wealth...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2016-12-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/9/12/1419 |
| _version_ | 1828304339832143872 |
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| author | Linda J. Mullins Bryan R. Conway Robert I. Menzies Laura Denby John J. Mullins |
| author_facet | Linda J. Mullins Bryan R. Conway Robert I. Menzies Laura Denby John J. Mullins |
| author_sort | Linda J. Mullins |
| collection | DOAJ |
| description | The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome engineering now allow us to capitalize on the wealth of knowledge acquired over the last century. Here, we review rat models of hypertension, diabetic nephropathy, and acute and chronic kidney disease. These models have made important contributions to our understanding of renal diseases and have revealed key genes, such as Ace and P2rx7, involved in renal pathogenic processes. By targeting these genes of interest, researchers are gaining a better understanding of the etiology of renal pathologies, with the promised potential of slowing disease progression or even reversing the damage caused. Some, but not all, of these target genes have proved to be of clinical relevance. However, it is now possible to generate more sophisticated and appropriate disease models in the rat, which can recapitulate key aspects of human renal pathology. These advances will ultimately be used to identify new treatments and therapeutic targets of much greater clinical relevance. |
| first_indexed | 2024-04-13T14:09:38Z |
| format | Article |
| id | doaj.art-5e2b82ec40dd485d849c393926b5e345 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-04-13T14:09:38Z |
| publishDate | 2016-12-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-5e2b82ec40dd485d849c393926b5e3452022-12-22T02:43:49ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112016-12-019121419143310.1242/dmm.027276027276Renal disease pathophysiology and treatment: contributions from the ratLinda J. Mullins0Bryan R. Conway1Robert I. Menzies2Laura Denby3John J. Mullins4 University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK University of Edinburgh/British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK The rat has classically been the species of choice for pharmacological studies and disease modeling, providing a source of high-quality physiological data on cardiovascular and renal pathophysiology over many decades. Recent developments in genome engineering now allow us to capitalize on the wealth of knowledge acquired over the last century. Here, we review rat models of hypertension, diabetic nephropathy, and acute and chronic kidney disease. These models have made important contributions to our understanding of renal diseases and have revealed key genes, such as Ace and P2rx7, involved in renal pathogenic processes. By targeting these genes of interest, researchers are gaining a better understanding of the etiology of renal pathologies, with the promised potential of slowing disease progression or even reversing the damage caused. Some, but not all, of these target genes have proved to be of clinical relevance. However, it is now possible to generate more sophisticated and appropriate disease models in the rat, which can recapitulate key aspects of human renal pathology. These advances will ultimately be used to identify new treatments and therapeutic targets of much greater clinical relevance.http://dmm.biologists.org/content/9/12/1419RatChronic kidney diseaseDiabetic nephropathyGenetically modified ratsEnd-organ damageRenal transplantation |
| spellingShingle | Linda J. Mullins Bryan R. Conway Robert I. Menzies Laura Denby John J. Mullins Renal disease pathophysiology and treatment: contributions from the rat Disease Models & Mechanisms Rat Chronic kidney disease Diabetic nephropathy Genetically modified rats End-organ damage Renal transplantation |
| title | Renal disease pathophysiology and treatment: contributions from the rat |
| title_full | Renal disease pathophysiology and treatment: contributions from the rat |
| title_fullStr | Renal disease pathophysiology and treatment: contributions from the rat |
| title_full_unstemmed | Renal disease pathophysiology and treatment: contributions from the rat |
| title_short | Renal disease pathophysiology and treatment: contributions from the rat |
| title_sort | renal disease pathophysiology and treatment contributions from the rat |
| topic | Rat Chronic kidney disease Diabetic nephropathy Genetically modified rats End-organ damage Renal transplantation |
| url | http://dmm.biologists.org/content/9/12/1419 |
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