Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis
Abstract Background The red cell index (RCI) was described as a biomarker for evaluating respiratory function in previous studies, but the relationship between RCI and stroke, remained a mystery. The present study aimed to probe the association between RCI at 24‐hr and 3‐month mortality and function...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2170 |
| _version_ | 1818448491248091136 |
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| author | Meizi Qian Xinbo Zhou Beibei Gao Honghao Huang Chenguang Yang Tian Zeng Jiamin Shen Jingyu Hu Fangyue Sun Shengqi Li Xuerong Huang Guangyong Chen |
| author_facet | Meizi Qian Xinbo Zhou Beibei Gao Honghao Huang Chenguang Yang Tian Zeng Jiamin Shen Jingyu Hu Fangyue Sun Shengqi Li Xuerong Huang Guangyong Chen |
| author_sort | Meizi Qian |
| collection | DOAJ |
| description | Abstract Background The red cell index (RCI) was described as a biomarker for evaluating respiratory function in previous studies, but the relationship between RCI and stroke, remained a mystery. The present study aimed to probe the association between RCI at 24‐hr and 3‐month mortality and functional outcomes among acute ischemic stroke (AIS) patients treated with recombinant tissue plasminogen activator (r‐tPA). Methods A total of 217 AIS patients between January 2016 and January 2019 were recruited in this retrospective study. AIS patients were grouped in terms of RCI tertiles. Predictive factors were confirmed via multivariate logistic regression analysis. The receiver operating characteristic (ROC) was used to assess the ability of RCI in predicting mortality. In addition, the risk of 3‐month all‐cause mortality was evaluated by Cox proportional hazard model. Results We grouped AIS patients into tertiles with the purpose of comparing clinical factors and RCI levels. Multivariate logistic regression analysis presented that RCI (odds ratio [OR] = 1.443, 95% confidence interval [CI] [1.167–1.786], p = 0.001) was an independent biomarker for 3‐month all‐cause mortality. The best cutoff value of RCI was 2.41 (area under the curve [AUC] = 0.639, 95% CI [0.501–0.778], p = .032), with a sensitivity of 40.9% and a specificity of 89.7%. Cox survival analysis demonstrated a positive significant correlation between RCI (hazard ratio [HR] = 1.332, 95% CI [1.148–1.545], p < .001) and mortality risk. Conclusion RCI, a potential predictor, was significantly associated with 3‐month mortality in AIS patients with r‐tPA. |
| first_indexed | 2024-12-14T20:20:21Z |
| format | Article |
| id | doaj.art-5e2e54b2ff9a4ac79b39a6133c308e69 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-14T20:20:21Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-5e2e54b2ff9a4ac79b39a6133c308e692022-12-21T22:48:45ZengWileyBrain and Behavior2162-32792021-06-01116n/an/a10.1002/brb3.2170Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysisMeizi Qian0Xinbo Zhou1Beibei Gao2Honghao Huang3Chenguang Yang4Tian Zeng5Jiamin Shen6Jingyu Hu7Fangyue Sun8Shengqi Li9Xuerong Huang10Guangyong Chen11Department of Anesthesia The First Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Internal Medicine The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaDepartment of Neurology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou ChinaAbstract Background The red cell index (RCI) was described as a biomarker for evaluating respiratory function in previous studies, but the relationship between RCI and stroke, remained a mystery. The present study aimed to probe the association between RCI at 24‐hr and 3‐month mortality and functional outcomes among acute ischemic stroke (AIS) patients treated with recombinant tissue plasminogen activator (r‐tPA). Methods A total of 217 AIS patients between January 2016 and January 2019 were recruited in this retrospective study. AIS patients were grouped in terms of RCI tertiles. Predictive factors were confirmed via multivariate logistic regression analysis. The receiver operating characteristic (ROC) was used to assess the ability of RCI in predicting mortality. In addition, the risk of 3‐month all‐cause mortality was evaluated by Cox proportional hazard model. Results We grouped AIS patients into tertiles with the purpose of comparing clinical factors and RCI levels. Multivariate logistic regression analysis presented that RCI (odds ratio [OR] = 1.443, 95% confidence interval [CI] [1.167–1.786], p = 0.001) was an independent biomarker for 3‐month all‐cause mortality. The best cutoff value of RCI was 2.41 (area under the curve [AUC] = 0.639, 95% CI [0.501–0.778], p = .032), with a sensitivity of 40.9% and a specificity of 89.7%. Cox survival analysis demonstrated a positive significant correlation between RCI (hazard ratio [HR] = 1.332, 95% CI [1.148–1.545], p < .001) and mortality risk. Conclusion RCI, a potential predictor, was significantly associated with 3‐month mortality in AIS patients with r‐tPA.https://doi.org/10.1002/brb3.2170biomarkermortalityprognosisred cell indexstroke |
| spellingShingle | Meizi Qian Xinbo Zhou Beibei Gao Honghao Huang Chenguang Yang Tian Zeng Jiamin Shen Jingyu Hu Fangyue Sun Shengqi Li Xuerong Huang Guangyong Chen Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis Brain and Behavior biomarker mortality prognosis red cell index stroke |
| title | Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis |
| title_full | Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis |
| title_fullStr | Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis |
| title_full_unstemmed | Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis |
| title_short | Red cell index: A novel biomarker for 3‐month mortality in acute ischemic stroke patients treated with intravenous thrombolysis |
| title_sort | red cell index a novel biomarker for 3 month mortality in acute ischemic stroke patients treated with intravenous thrombolysis |
| topic | biomarker mortality prognosis red cell index stroke |
| url | https://doi.org/10.1002/brb3.2170 |
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