Estimating renal and hepatic clearance rates of organophosphate esters in humans: Impacts of intrinsic metabolism and binding affinity with plasma proteins

Estimating renal and hepatic clearance rates of organophosphate esters in humans: Impacts of intrinsic metabolism and binding affinity with plasma proteins

The renal and hepatic clearance rates of organophosphate esters (OPEs) in humans were estimated. Six OPEs and their corresponding diester metabolites (mOPEs) were quantified respectively in 30 paired human plasma and urine samples collected in Hengshui, Hebei province, China. The renal clearance rat...

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Bibliographic Details
Main Authors: Xiaolei Wang, Qing Liu, Wenjue Zhong, Liping Yang, Jing Yang, Adrian Covaci, Lingyan Zhu
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Environment International
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412019332544

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